TRIB2 Antibody (YA4397)
(Synonyms: C5FW; TRB2; GS3955)TRIB2 Antibody (YA4397) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to TRIB2.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
TRIB2 Antibody (YA4397) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to TRIB2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 39 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 38.8 kDa
Purified recombinant fragment of human TRIB2 (AA: 1-200) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TRIB2 is a Tribbles homolog 2 (TRIB2) is a pseudokinase that functions as a molecular adaptor mediating degradation and changes to signalling cascades. TRIB2 is also shown to be a potent oncogene in a variety of malignancies, including myeloid and lymphoid leukaemia, melanoma, lung cancer, and liver cancer. The oncogenic activity of TRIB2 is linked to its dysregulated expression, rather than its dysregulation via mutation in the majority of cancers. One of the most characterized substrates for TRIB2-mediated degradation is the myeloid transcription factor CCAAT enhancer binding protein α (C/EBPα). However, across a number of cancers, the molecular interactions that take place between TRIB2 and factors involved in the UPS are varied and have differential downstream effects[1].
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Subcellular Localization
Cytoplasm; cytoskeleton
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Expression
Tissue specificity: Highly expressed in peripheral blood leukocytes. -
Subunit
Interacts with COP1.
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SwissProt ID
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Synonyms
C5FW; TRB2; GS3955
Documentation
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