TRIB2 - tribbles pseudokinase 2 Gene

Also Known as C5FW; TRB2; GS3955

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 28951

About TRIB2

Cytogenetic location: 2p24.3 Genomic coordinates (GRCh38): 2:12,716,936-12,742,734 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 31.3), spleen (RPKM 27.6) and 24 other tissues.

Summary

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces Apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

TRIB2 Products (1)

mRNA	Protein	Name
NM_021643.4	NP_067675.1	tribbles homolog 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	18643775	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIB2 Protein Structure

Pkinase

0
100
200
300
343 a.a.

Protein Preferred Names	Protein Names
tribbles homolog 2

TRIB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIB2	Q92519	PARVG	Homo sapiens	Q9HBI0	Validated Y2H	32296183
Intra	TRIB2	Q92519	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	TRIB2	Q92519	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	TRIB2	Q92519	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TRIB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74492	TRIB2 Protein, Human (sf9, His-GST)	Q92519 (M1-N343)	≥ 90%, as determined by reducing SDS-PAGE.

TRIB2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84700	TRIB2 Antibody (YA4397)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84700A	TRIB2 Antibody (YA4397)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84701	TRIB2 Antibody (YA4398)	WB, ICC/IF, FC, ELISA	Human
HY-P84701A	TRIB2 Antibody (YA4398)(PBS only)	WB, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Autoimmune Uveitis
Uveitis
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-168274	PROTAC TRIB2 degrader-1	Inducer	/	Unkown
HY-184178A	HF-125	Inducer	/	Unkown
HY-168275	TRIB2 ligand-1	Ligand	/	Unkown
HY-168276	Boc-Nonanol		/	Unkown
HY-168277	5-Aminothalidomide-C9-Boc		/	Unkown
HY-RS15016	TRIB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19489	Trib2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25983	Trib2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRIB2	VGNC	VGNC:81252
Macaca mulatta	TRIB2	VGNC	VGNC:106242
Canis familiaris	TRIB2	VGNC	VGNC:47801
Rattus norvegicus	TRIB2	RGD	RGD:1564451
Bos taurus	TRIB2	VGNC	VGNC:36309
Mus musculus	TRIB2	MGD	MGI:2145021
Others	TRIB2	NCBI