2. Gene
  3. TRIB2 - tribbles pseudokinase 2 Gene

TRIB2 - tribbles pseudokinase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as C5FW; TRB2; GS3955

Gene ID: 28951 | Gene type: protein coding

About TRIB2

Cytogenetic location: 2p24.3 Genomic coordinates (GRCh38): 2:12,716,936-12,742,734 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 31.3), spleen (RPKM 27.6) and 24 other tissues.

Summary

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces Apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

TRIB2 Products(1)

mRNA Protein Name
NM_021643.4 NP_067675.1 tribbles homolog 2

TRIB2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (75 - 308)

  • 0
  • 100
  • 200
  • 300
  • 343 a.a.
Protein Preferred Names Protein Names

tribbles homolog 2

Recombinant TRIB2 Proteins

Cat. No. Product Name Accession Purity
HY-P74492 TRIB2 Protein, Human (sf9, His-GST) Q92519 (M1-N343) ≥95%

Related Diseases

Diseases Alias
Autoimmune Uveitis
Uveitis
Narcolepsy

Paroxysmal Sleep

Gelineau Syndrome

Narcoleptic Syndrome

Narcolepsy-Cataplexy Syndrome

Cataplexy And Narcolepsy

Narcolepsy, Without Cataplexy

Gelineau'S Syndrome

Narcolepsy With Or Without Cataplexy

Narcolepsy Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15016 TRIB2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRIB2 VGNC VGNC:81252
Macaca mulatta TRIB2 VGNC VGNC:106242
Canis familiaris TRIB2 VGNC VGNC:47801
Rattus norvegicus TRIB2 RGD RGD:1564451
Bos taurus TRIB2 VGNC VGNC:36309
Mus musculus TRIB2 MGD MGI:2145021
Others TRIB2 NCBI