Antifungal agent 42

Cat. No.: HY-151440: Data Sheet Handling Instructions
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Antifungal agent 42 is an antifungal agent. Antifungal agent 42 has an inhibitory effect on lanosterol 14α-demethylase (CYP51) of C.alb.. Antifungal agent 42 inhibits biofilm formation.

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Antifungal agent 42 화학구조

CAS No. : 3033703-25-9

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Antifungal agent 42 is an antifungal agent. Antifungal agent 42 has an inhibitory effect on lanosterol 14α-demethylase (CYP51) of C.alb.. Antifungal agent 42 inhibits biofilm formation^[1].

IC₅₀ & Target

CYP51^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	12.5 μM Compound: B03	Cytotoxicity against human HL-60 cells by MTT assay Cytotoxicity against human HL-60 cells by MTT assay	[PMID: 36057236]
MDA-MB-231	IC₅₀	5.5 μM Compound: B03	Cytotoxicity against human MDA-MB-231 cells by MTT assay Cytotoxicity against human MDA-MB-231 cells by MTT assay	[PMID: 36057236]
PC-3	IC₅₀	2.91 μM Compound: B03	Cytotoxicity against human PC-3 cells by MTT assay Cytotoxicity against human PC-3 cells by MTT assay	[PMID: 36057236]

In Vitro

Antifungal agent 42 (compound B03, 0.25-128 μg/mL) inhibits fungal activity with MIC values of 1-64 μg/mL^[1].
Antifungal agent 42 (0.5 μg/mL, 1.5-24 h) displays antibiofilm activity against FCZ-Resistant C.alb^[1].
Antifungal agent 42 (0-20 μM approximately) shows cytotoxicity against HL-60, MDA-MB-231 and PC-3 cells with IC₅₀ values of 12.5, 5.5, 2.91 μM respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

569.25

화학식

C₂₂H₂₀Cl₂N₄Se₂

CAS No.

3033703-25-9

SMILES

ClC1=CC=C(C([Se][Se]C(C2=CC=C(Cl)C=C2)CN3C=CN=C3)CN4C=CN=C4)C=C1

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Hang Xu, et al. Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51. Eur J Med Chem. 2022 Aug 28;243:114707. [Content Brief]