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Art. -Nr.: HY-117524

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FTI-249

FTI-249 is a farnesyl transferase inhibitor with an IC₅₀ of 100-200 nM. FTI-249 acts as a linear competitive inhibitor targeting the peptide substrate of farnesyl transferase. FTI-249 is applicable for cancer research.

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CAS. Nr.: 161721-65-9
Formel: C₁₅H₂₃N₃O₃S₂
Molecular Weight:357.49

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

FTI-249 Chemical Structure

CAS. Nr.: 161721-65-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

FTI-249 (100 nM; up to 50 min) acts as a classical linear competitive inhibitor of recombinant rat FTase, producing linear product formation kinetics when used at 100 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS. Nr. 161721-65-9
Molecular Weight 357.49
Formel C₁₅H₂₃N₃O₃S₂
SMILES

CSCC[C@@H](C(O)=O)NC(C1=CC=C(C=C1)NC[C@@H](N)CS)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Sebti SM, et al. Inhibition of Ras prenylation: a novel approach to cancer chemotherapy. Pharmacology & therapeutics. 1997;74(1):103-14. [Content Brief]

[2]. Roskoski R, et al. Time-dependent inhibition of protein farnesyltransferase by a benzodiazepine peptide mimetic. Biochemistry. 2001 Aug 07;40(31):9329-35. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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