Birc5 - baculoviral IAP repeat-containing 5 Gene

Also Known as Api4; TIAP; AAC-11; survivin40

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11799

Summary

This gene is a member of the inhibitor of Apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]

Birc5 Products (2)

mRNA	Protein	Name
NM_001012273.1	NP_001012273.1	baculoviral IAP repeat-containing protein 5 isoform 3
NM_009689.2	NP_033819.1	baculoviral IAP repeat-containing protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17881355	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	11084331	MGI
involved in meiosis I	IDA IDA: Inferred from direct assay	25645018	MGI
acts upstream of or within microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	11084331	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12679106	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	25778398	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16049172	MGI
acts upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	19644667	MGI
acts upstream of or within regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	19644667	MGI
acts upstream of or within regulation of type B pancreatic cell proliferation	IMP IMP: Inferred from mutant phenotype	19644667	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
is active in chromosome, centromeric region	IDA IDA: Inferred from direct assay	25645018	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12679106	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
baculoviral IAP repeat-containing protein 5	apoptosis inhibitor 4 apoptosis inhibitor survivin survivin

Recombinant Birc5 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P71717	Apoptosis inhibitor 4/Birc5 Protein, Mouse (P.pastoris, His)	O70201 (M1-A140)	≥ 90%, as determined by reducing SDS-PAGE.

Birc5 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P87097	Survivin Antibody (YA6790)	WB, IHC-P, IP	Mouse, Rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-124447	BTYNB		98.0%	Unkown
HY-173025	Nurr1 agonist 12	Agonist	99.62%	Unkown
HY-175352	Nurr1 agonist 14		99.42%	Unkown
HY-RS01513	BIRC5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17902	Birc5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24371	Birc5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Birc5	NCBI	NCBI:332