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Art. -Nr.: HY-P2593

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L-659874

L-659874 is a selective NK2 receptor antagonist with an IC₅₀ value of 0.49 μM in hamsters. L-659874 inhibits NK2 receptor-mediated hydrolysis of inositol phospholipids. L-659874 could be used for research on the correlation between pain signal transduction and smooth muscle responses.

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CAS. Nr.: 125989-15-3
Formel: C₄₀H₅₅N₉O₈S
Molecular Weight:822.00

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

L-659874 Chemical Structure

CAS. Nr.: 125989-15-3

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Hamster Bladder NK-2

0.49 μM (IC₅₀)

Alle Neurokinin Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

L-659874 (preincubated for 15 min prior to stimulation with Eledoisin (HY-P0006); co-incubated with Eledoisin for a total duration of 45 min at 0.01-100 μM) potently inhibits NK₂ receptor-mediated Eledoisin-induced phosphatidylinositol hydrolysis in hamster bladder slices, with an IC₅₀ of 0.49 μM^[1].
L-659874 blocks the binding of iodine-125-labeled BH-Eledoisin to hamster bladder cell membranes, with an IC₅₀ of 0.04 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 125989-15-3
Molecular Weight 822.00
Formel C₄₀H₅₅N₉O₈S
SMILES

C([C@@H](C(N[C@@H](CC1=CC=CC=C1)C(NCC(N)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)CCSC)=O)CCC(N)=O)=O)C=2C=3C(NC2)=CC=CC3
Sequence

Ac-Leu-Met-Gln-Trp-Phe-Gly-NH2
Sequence Shortening

Ac-LMQWFG-NH2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Suman-Chauhan N, et al. Pharmacological characterization of tachykinin-stimulated inositol phospholipid hydrolysis in peripheral tissues. Br J Pharmacol. 1990;101(4):1001-1005. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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L-659874

Alle Neurokinin Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

L-659874 Related Classifications

HY-P2593 Related Classifications