SDH-IN-46
SDH-IN-46 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 1.21 μM. SDH-IN-46 disrupts fungal respiration via mitochondrial respiratory chain enzyme targeting and exhibits broad-spectrum antifungal activity. SDH-IN-46 exhibits substantial protective effects against S. sclerotiorum on oilseed rape leaves, Rhizoctonia solani on rice leaves, and Valsa mali on apple fruits.
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- Formel: C18H13F5N4O
- Molecular Weight:396.31
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
In Vitro
SDH-IN-46 (Compound 6i) (20 μg/mL) inhibits mycelial growth of Rhizoctonia solani, Sclerotinia sclerotiorum, Valsa mali, Fusarium graminearum, and Botrytis cinerea by 66.2-92.4%[1].
SDH-IN-46 potently inhibits mycelial growth of Sclerotinia sclerotiorum with an EC50 of 0.44 μg/mL, and inhibits Rhizoctonia solani, Valsa mali, Fusarium graminearum, and Botrytis cinerea with EC50 values ranging from 1.05-5.41 μg/mL[1].
SDH-IN-46 potently inhibits Sclerotinia sclerotiorum succinate dehydrogenase with an IC50 of 1.21 μM[1].
SDH-IN-46 (1 μg/mL) causes significant structural damage to Sclerotinia sclerotiorum hyphae, including wrinkling, shrinkage, and rupture[1].
SDH-IN-46 (100 μg/mL) shows protective efficacy against S. sclerotiorum on oilseed rape leaves, R. solani on rice leaves, and V. mali on apple fruits[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 396.31
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Formel C18H13F5N4O
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SMILES
O=C(NC1=CN(C)N=C1C(F)F)C2=CC=CC=C2NC3=CC(F)=C(F)C(F)=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SDH-IN-46 Related Classifications
HY-183722 Related Classifications
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