1. Cell Cycle/DNA Damage
    Epigenetics
  2. Aurora Kinase
  3. Aurora kinase inhibitor-2

Aurora kinase inhibitor-2 

Cat. No.: HY-112355 Purity: 99.19%
Handling Instructions

Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively.

For research use only. We do not sell to patients.

Aurora kinase inhibitor-2 Chemical Structure

Aurora kinase inhibitor-2 Chemical Structure

CAS No. : 331770-21-9

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
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Description

Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively[1].

IC50 & Target[1]

Aurora A

310 nM (IC50)

Aurora B

240 nM (IC50)

In Vitro

Aurora kinase inhibitor-2 (Compound 1) shows excellent levels of Aurora A enzyme inhibition and is also effective in an MCF7 cellular anti-proliferative assay (IC50 value of 1.25 µM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

400.43

Formula

C₂₃H₂₀N₄O₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (249.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4973 mL 12.4866 mL 24.9732 mL
5 mM 0.4995 mL 2.4973 mL 4.9946 mL
10 mM 0.2497 mL 1.2487 mL 2.4973 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.19 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Aurora kinase inhibitor-2
Cat. No.:
HY-112355
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