AXL/Angiokinase-IN-1
AXL/Angiokinase-IN-1 (compound 11b) is an AXL/triple angiokinase inhibitor, IC50=3.75 nM (AXL expression). AXL/Angiokinase-IN-1 inhibits epithelial-mesenchymal transition (EMT) in Bxpc-3, blocking lung cancer cell metastasis. AXL/Angiokinase-IN-1 also inhibits vascular and fibroblast functions, promoting apoptosis (apoptosis) in cancer cells and fibroblasts. AXL/Angiokinase-IN-1 features low toxicity and good metabolic stability.
For research use only. We do not sell to patients.
- Formula: C31H34ClN5O2
- Molecular Weight:544.09
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
Chemical Information
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Molecular Weight 544.09
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Formula C31H34ClN5O2
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SMILES
O=C1NC2=CC(Cl)=CC=C2/C1=C(C3=CC=CC=C3)/NC4=CC=C(C=C4)N(C)C(C(C)N5CCN(CC5)CC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AXL/Angiokinase-IN-1 Related Classifications
HY-170776 Related Classifications
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