BACE1-IN-4 

BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC₅₀ of 3.8 nM and a K_i of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer’s disease^[1].

BACE1-IN-4 (Compound 22) is a potent and highly selective BACE1 inhibitor, with an IC₅₀ of 3.8 nM and a K_i of 1.9 nM, more selective at BACE1 over BACE2 (IC₅₀, 2090 nM; K_i, 1740 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

511.57

C₂₁H₂₃F₂N₅O₄S₂

2361157-92-6

NC1=N[C@@](C2=CC(NC(C3=NC=C(OCF)N=C3)=O)=CC=C2F)(C)C4(CCS(CC4)(=O)=O)CS1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Fujimoto K, et al. Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2. J Med Chem. 2019 May 23;62(10):5080-5095.  [Content Brief]