2361157-92-6
2361157-92-6
Chemical Structure
BACE1-IN-4
- CAS No.: 2361157-92-6
- Formula:C21H23F2N5O4S2
- Molecular Weight:511.57
IUPAC Name: (R)-N-(3-(3-amino-5-methyl-9,9-dioxido-2,9-dithia-4-azaspiro[5.5]undec-3-en-5-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide
InChIKey: DZTJZUAOGBUBNK-HXUWFJFHSA-N
SMILES: NC1=N[C@@](C2=CC(NC(C3=NC=C(OCF)N=C3)=O)=CC=C2F)(C)C4(CCS(CC4)(=O)=O)CS1
Biological Activity: BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer’s disease[1].
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BACE1-IN-4 | BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer’s disease. | |||||||||||||||||||||
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References
Keywords
