BCL-xL ligand 5
BCL-xL ligand 5 is a Bcl-xL ligand with an IC50 of 0.5 nM. BCL-xL ligand 5 can be used for the synthesis of PROTACs, such as PROTAC Bcl-xL degrader-2 (HY-139309).
For research use only. We do not sell to patients.
- CAS No.: 1235033-76-7
- Formula: C35H33N5O4S2
- Molecular Weight:651.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Bcl-xL 0.5 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H146 | EC50 |
0.6 μM
Compound: 15
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Cytotoxicity against BCL-XL-dependent human NCI-H146 cells in presence of 10% human serum incubated for 48 hrs by Cell titerGlo reagent based assay
Cytotoxicity against BCL-XL-dependent human NCI-H146 cells in presence of 10% human serum incubated for 48 hrs by Cell titerGlo reagent based assay
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[PMID: 25313317] |
In Vitro
BCL-xL ligand 5 (Compound 5b) potently inhibits FAM-Bad peptide binding to purified Bcl-xL protein with an IC50 of 0.5 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1235033-76-7
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Molecular Weight 651.80
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Formula C35H33N5O4S2
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SMILES
O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BCL-xL ligand 5 Related Classifications
HY-184713 Related Classifications
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