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Cat. No.: HY-184713

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BCL-xL ligand 5

BCL-xL ligand 5 is a Bcl-xL ligand with an IC₅₀ of 0.5 nM. BCL-xL ligand 5 can be used for the synthesis of PROTACs, such as PROTAC Bcl-xL degrader-2 (HY-139309).

For research use only. We do not sell to patients.

CAS No.: 1235033-76-7
Formula: C₃₅H₃₃N₅O₄S₂
Molecular Weight:651.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BCL-xL ligand 5 Chemical Structure

CAS No.: 1235033-76-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

BCL-xL ligand 5 is a Bcl-xL ligand with an IC₅₀ of 0.5 nM. BCL-xL ligand 5 can be used for the synthesis of PROTACs, such as PROTAC Bcl-xL degrader-2 (HY-139309)^[1].

IC₅₀ & Target^[1]

Bcl-xL

0.5 nM (IC₅₀)

All Bcl-2 Family Isoforms :

In Vitro

BCL-xL ligand 5 (Compound 5b) potently inhibits FAM-Bad peptide binding to purified Bcl-xL protein with an IC₅₀ of 0.5 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1235033-76-7
Molecular Weight 651.80
Formula C₃₅H₃₃N₅O₄S₂
SMILES

O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chung CW, et al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS chemical biology. 2020 Sep 18;15(9):2316-2323. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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BCL-xL ligand 5

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BCL-xL ligand 5 Related Classifications

HY-184713 Related Classifications