Propargyl-PEG2-OH
Based on 1 Customer Validation
Propargyl-PEG2-OH is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458). Propargyl-PEG2-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 99.66%
- CAS No.: 7218-43-1
- Formula: C7H12O3
- Molecular Weight:144.17
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 7218-43-1
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Appearance Liquid (Density: 1.06 g/cm3)
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Molecular Weight 144.17
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Formula C7H12O3
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Color Colorless to light yellow
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SMILES
C#CCOCCOCCO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
Ethanol : ≥ 100 mg/mL (693.63 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 6.9363 mL | 34.6813 mL | 69.3626 mL | 173.4064 mL |
| 5 mM | 1.3873 mL | 6.9363 mL | 13.8725 mL | 34.6813 mL | |
| 10 mM | 0.6936 mL | 3.4681 mL | 6.9363 mL | 17.3406 mL | |
| 15 mM | 0.4624 mL | 2.3121 mL | 4.6242 mL | 11.5604 mL | |
| 20 mM | 0.3468 mL | 1.7341 mL | 3.4681 mL | 8.6703 mL | |
| 25 mM | 0.2775 mL | 1.3873 mL | 2.7745 mL | 6.9363 mL | |
| 30 mM | 0.2312 mL | 1.1560 mL | 2.3121 mL | 5.7802 mL | |
| 40 mM | 0.1734 mL | 0.8670 mL | 1.7341 mL | 4.3352 mL | |
| 50 mM | 0.1387 mL | 0.6936 mL | 1.3873 mL | 3.4681 mL | |
| 60 mM | 0.1156 mL | 0.5780 mL | 1.1560 mL | 2.8901 mL | |
| 80 mM | 0.0867 mL | 0.4335 mL | 0.8670 mL | 2.1676 mL | |
| 100 mM | 0.0694 mL | 0.3468 mL | 0.6936 mL | 1.7341 mL |
Propargyl-PEG2-OH Related Classifications
HY-130541 Related Classifications
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