Rosopatamab
Based on 1 Customer Validation
Rosopatamab (HuJ591) is a humanized antiPSMA IgG1 monoclonal antibody that can be used in cancer research, especially prostate cancer. Rosopatamab can be linked to the low-energy beta-emitting radioisotope lutetium-177 (177Lu) through the bifunctional chelator DOTA-NHS ester to obtain a radioimmunoconjugate that targets malignant prostate cells with high efficiency.
For research use only. We do not sell to patients.
- Purity: 99.47%
- CAS No.: 2260767-49-3
- Molecular Weight:144.11 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
Human IgG1 kappa
Human
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FOLH1/PSMA |
RDC Antibody |
177Lu-rosopatamab (anti-PSMA) (6 MBq, i.v., single) plus Peposertib (HY-101570) has 75% complete response (3/4) vs 25% complete response (1/4) in the 177Lu-anti-PSMA (6MBq) alone arm in the prostate BALB/c nude mice model[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized PSMA Protein, Human (HEK293, His, HY-P70548A) can bind Rosopatamab. The EC50 for this effect is 88.78 ng/mL.
Chemical Information
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CAS No. 2260767-49-3
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Appearance Liquid
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Molecular Weight 144.11 kDa
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Color Colorless to light yellow
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SMILES
[Rosopatamab]
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Synonyms
HUJ-591; TLX591
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)