7-Coumaryl triflate
Based on 1 Customer Validation
7-Coumaryl triflate is a type 17β-HSD1 inhibitor of 17β-hydroxysteroid dehydrogenase. Its IC50 is 360 nM and Ki is 173 nM. 7-Coumaryl triflate shows selectivity for 17β-HSD2 and has no detectable affinity for ERα or ERβ. 7-Coumaryl triflate can be used in related research on hormone-dependent breast cancer.
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- CAS No.: 108530-10-5
- Formule: C10H5F3O5S
- Masse moléculaire:294.20
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Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
7-Coumaryl triflate (0.6-6 μM; 10 min) potently inhibits recombinant human 17β-HSD1 overexpressed in E. coli with an IC50 of 360 nM, showing 60% and 100% inhibition at 0.6 μM and 6 μM, respectively[1].
7-Coumaryl triflate (60 μM) does not inhibit recombinant human 17β-HSD2 overexpressed in E. coli at 60 μM, confirming high selectivity for 17β-HSD1 over 17β-HSD2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 108530-10-5
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Appearance Solid
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Masse moléculaire 294.20
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Formule C10H5F3O5S
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Color Off-white to brown
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SMILES
O=C1OC=2C=C(OS(=O)(=O)C(F)(F)F)C=CC2C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Pureté et documentation
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Fiche technique (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
7-Coumaryl triflate Related Classifications
HY-43322 Related Classifications
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