MB-07803
MB-07803 is an orally active fructose-1,6-bisphosphatase (FBP1) inhibitor and a derivative of CS-917 (HY-14955). MB-07803 inhibits the rate-limiting enzyme in gluconeogenesis. MB07803 is converted as a prodrug to the active metabolite MB07729. MB-07803 controls blood glucose and is used in research on type 2 diabetes.
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- CAS No.: 882757-24-6
- Formule: C24H37N4O7PS
- Masse moléculaire:556.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
31, 121, 189 nM for human, monkey, and rat, respectively [1] .
In Vitro
MB-07803 is a prodrug form of an FBP1 inhibitor and a CS‑917 derivative that can be converted to generate the active metabolite MB07729[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 882757-24-6
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Masse moléculaire 556.61
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Formule C24H37N4O7PS
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SMILES
O=C(C(C)(C)NP(NC(C)(C)C(OCC)=O)(C1=CC=C(C2=C(C(C(C)(C)C)=O)SC(N)=N2)O1)=O)OCC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MB-07803 Related Classifications
HY-16309 Related Classifications
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