Apidaecin IA
Apidaecin IA is a basic peptide. Apidaecin IA inhibits the enzymatic activity of DnaK. Apidaecin IA induces bacterial cell death. Apidaecin IA can be used in research related to peritonitis and bacterial infections.
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- CAS No.: 123081-48-1
- Formule: C95H150N32O23
- Masse moléculaire:2108.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
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DnaK |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CEM-SS | EC50 |
>47.4 μM
Compound: Apidaecin IA
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Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by XTT assay
Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by XTT assay
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[PMID: 20086159] |
In Vitro
Apidaecin IA (100 ng/mL; 8 h) inhibits DnaK activity and binds LPS (HY-D1056), reducing bacterial survival by approximately 2 log10 at 8 h post-induction[1].
Apidaecin IA (0.02-200 μg/mL) potently inhibits the growth of a variety of Gram-negative bacterial strains, with its MIC values ranging from 0.02 μg/mL to 0.2 μg/mL[2].
Apidaecin IA (100 μg/mL) exhibits antibacterial activity against Escherichia coli NCTC 9001 cells. It inhibits the growth of the cells without causing immediate lysis, and does not interfere with the phospholipid bilayer[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 123081-48-1
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Masse moléculaire 2108.41
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Formule C95H150N32O23
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Sequence
Gly-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Gln-Pro-Arg-Pro-Pro-His-Pro-Arg-Ile
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Sequence Shortening
GNNRPVYIPQPRPPHPRI
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Structure Classification
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Initial Source
honeybee
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apidaecin IA Related Classifications
HY-P5721 Related Classifications
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