Dynamin inhibitory peptide
Based on 1 publication(s) in Google Scholar
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 96.09%
- CAS No.: 251634-21-6
- Formule: C47H80N18O14
- Masse moléculaire:1121.25
-
Stockage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-13863
Hydroxy-DynasoreDynamin I/II Inhibitor -
HY-15886
Mdivi-1Drp1 Inhibitor -
HY-15304
DynasoreAutophagy Inducer -
HY-13948
Angiotensin II humanVasoconstrictor -
HY-P1082
Gap 26Gap Junction Inhibitor -
HY-P0139
Gap 27Gap Junction Inhibitor -
HY-107545
Dynole 34-2Dynamin GTPase Inhibitor -
HY-P1087
AdrenorphinOpioid Receptor Agonist -
HY-P1137
10PanxBioactive Peptide -
HY-15304R
Dynasore (Standard)Autophagy Inducer -
HY-W013158
Trimethyloctadecylammonium bromideDynamin Inhibitor -
HY-P1540
Angiotensin III, human, mouseAT2R Agonist
Publications Citing Use of MedChemExpress (MCE) Dynamin inhibitory peptide
More
Activité biologique
Description
In Vitro
Chemical Information
-
CAS No. 251634-21-6
-
Appearance Solid
-
Masse moléculaire 1121.25
-
Formule C47H80N18O14
-
Color White to off-white
-
Sequence
Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro
-
Sequence Shortening
QVPSRPNRAP
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Cell Rep
Deletion of histamine H2 receptor in VTA dopaminergic neurons of mice induces behavior reminiscent of mania. [Abstract]2024 Sep 10;43(9):114717. PMID: 39264811
Solvant et solubilité
In Vitro:
DMSO : 50 mg/mL (44.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (1.11 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (1.11 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
-
Fiche technique (280 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8919 mL | 4.4593 mL | 8.9186 mL | 22.2965 mL |
| 5 mM | 0.1784 mL | 0.8919 mL | 1.7837 mL | 4.4593 mL | |
| 10 mM | 0.0892 mL | 0.4459 mL | 0.8919 mL | 2.2297 mL | |
| 15 mM | 0.0595 mL | 0.2973 mL | 0.5946 mL | 1.4864 mL | |
| 20 mM | 0.0446 mL | 0.2230 mL | 0.4459 mL | 1.1148 mL | |
| 25 mM | 0.0357 mL | 0.1784 mL | 0.3567 mL | 0.8919 mL | |
| 30 mM | 0.0297 mL | 0.1486 mL | 0.2973 mL | 0.7432 mL | |
| 40 mM | 0.0223 mL | 0.1115 mL | 0.2230 mL | 0.5574 mL |
Dynamin inhibitory peptide Related Classifications
HY-P1083 Related Classifications
Powered by Bioz