Vdr - vitamin D receptor Gene

Also Known as Nr1i1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24873

About Vdr

Primary_assembly 7: 128,987,981-129,037,677 reverse strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 462 orthologues, 19 paralogues and is associated with 109 phenotypes. Biased expression in Kidney (RPKM 182.4), Lung (RPKM 16.2) and 3 other tissues.

Summary

Enables calcitriol binding activity; nuclear receptor activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of bone trabecula formation; and positive regulation of parathyroid hormone secretion. Located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Colocalizes with caveola. Used to study vitamin D-dependent rickets type 2A. Biomarker of secondary hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2022]

Vdr Products (1)

mRNA Protein Name
NM_017058.2 NP_058754.2 vitamin D3 receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables calcitriol binding IDA
IDA: Inferred from direct assay
8179318 RGD
enables nuclear receptor activity IDA
IDA: Inferred from direct assay
9579411 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19074549 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16481392 RGD
enables vitamin D binding IDA
IDA: Inferred from direct assay
2829212 RGD
enables vitamin D binding IMP
IMP: Inferred from mutant phenotype
2829212 RGD
Biological Process GO Annotation Evidence Références Source
involved in apoptotic signaling pathway IDA
IDA: Inferred from direct assay
9579411 RGD
involved in cellular response to amyloid-beta IEP
IEP: Inferred from expression pattern
23752060 RGD
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
9753201 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
12107506 RGD
involved in negative regulation of bone trabecula formation IMP
IMP: Inferred from mutant phenotype
32231239 RGD
involved in negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
32231239 RGD
involved in positive regulation of parathyroid hormone secretion IMP
IMP: Inferred from mutant phenotype
32231239 RGD
involved in regulation of calcium ion transport IDA
IDA: Inferred from direct assay
18353900 RGD
involved in response to aldosterone IEP
IEP: Inferred from expression pattern
29713904 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
20181667 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
10724336 RGD
Cellular Component GO Annotation Evidence Références Source
located in T-tubule IDA
IDA: Inferred from direct assay
20015453 RGD
located in caveola IDA
IDA: Inferred from direct assay
15272054 RGD
located in dense fibrillar component IDA
IDA: Inferred from direct assay
8392883 RGD
located in euchromatin IDA
IDA: Inferred from direct assay
8392883 RGD
located in heterochromatin IDA
IDA: Inferred from direct assay
8392883 RGD
located in nuclear matrix IDA
IDA: Inferred from direct assay
9744521 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
9220147 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Vdr Protein Structure

NR_DBD_VDR

NR_DBD_VDR: cd06955 (15 - 121)

NR_LBD_VDR

NR_LBD_VDR: cd06933 (123 - 421)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
Protein Preferred Names Protein Names

vitamin D3 receptor

  • 1,25-dihydroxyvitamin D3 receptor

  • nuclear receptor subfamily 1 group I member 1

  • vitamin D (1,25- dihydroxyvitamin D3) receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-10002 Calcitriol Agonist 99.94% Unkown
HY-32351 Calcifediol 99.94% Unkown
HY-10003 Alfacalcidol Activator 99.96% Unkown
HY-32339 Maxacalcitol Activator 99.71% Unkown
HY-32351A Calcifediol monohydrate 99.98% Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit Effect
Pureté Phase
HY-32344 Inecalcitol 98.44% Phase 2
HY-32345 Elocalcitol 99.2% Phase 2
HY-14863 Lunacalcipol / Phase 2
HY-32351S3 Calcifediol-d9 / Phase 2
HY-B1844 Flucythrinate / Phase 1

Pre-clinical Phase

Bioactive Molecules (60)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-147337 MeTC7 Antagonist 98.50% Unkown
HY-32343 Secalciferol Activator 99.85% Unkown
HY-12407 ZK168281 Antagonist 98.0% Unkown
HY-76814 Calcitriol-d6 Activator 99.27% Unkown
HY-32350 Ercalcitriol Activator 99.71% Unkown
HY-13332 Calcifediol-d6 Activator 99.09% Unkown
HY-12398 TEI-9647 Agonist 99.10% Unkown
HY-103053 PS121912 Inhibitor 96.40% Unkown
HY-10002A (1S)-Calcitriol 98.52% Unkown
HY-12397 ZK159222 Antagonist 99.23% Unkown
HY-12398A TEI-9648 Inhibitor 99.24% Unkown
HY-77278 25-Hydroxytachysterol3 Agonist 98.07% Unkown
HY-15329 Maxacalcitol-d6 Activator 96.03% Unkown
HY-32351S Calcifediol-d3 98.96% Unkown
HY-131492 Δ4-Dafachronic acid Ligand 96.93% Unkown
HY-RS15632 VDR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-131961 Triciferol 98.61% Unkown
HY-N10508 Calcitroic acid Agonist 85.0% Unkown
HY-13294 Impurity C of Alfacalcidol Activator 99.81% Unkown
HY-15332 Alfacalcidol-d6 Activator 98.0% Unkown
HY-32351AS Calcifediol-d6 monohydrate 97.50% Unkown
HY-13293 Impurity C of Calcitriol Activator 99.84% Unkown
HY-RS15633 Vdr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-154825 20-Hydroxyvitamin D3 ≥98.0% Unkown
HY-77274 Calcitriol Impurities D Activator 95.18% Unkown
HY-114310 VDR agonist 1 / Unkown
HY-10002B (1R,5Z)-Calcitriol Control / Unkown
HY-119612 XCT0135908 / Unkown
HY-10002AS (1S)-Calcitriol-d3 / Unkown
HY-10002AS2 (1S)-Calcitriol-d6 / Unkown
HY-10002S1 Calcitriol-d3 / Unkown
HY-10002S2 Calcitriol-d9 / Unkown
HY-10003S Alfacalcidol-d7 Activator / Unkown
HY-117182 LG190178 / Unkown
HY-118970 LG190155 / Unkown
HY-131492S Δ4-Dafachronic Acid-d3 Ligand / Unkown
HY-149899 VDR agonist 2 Agonist / Unkown
HY-15364 19-nor-1α,25-Dihydroxyvitamin D3 Ligand / Unkown
HY-161778 ZG-126 / Unkown
HY-163947 UG-480 Modulator / Unkown
HY-166525S 24R-Calcipotriol-d4 Activator / Unkown
HY-170975 UG-650 Ligand / Unkown
HY-172087 VDR agonist 3 Agonist / Unkown
HY-173393 LXRα agonist 1 Agonist / Unkown
HY-178328 VDR agonist 4 / Unkown
HY-178336 AC-340 / Unkown
HY-179431 VDR ligand-1 Agonist / Unkown
HY-181486 VDR agonist 5 Agonist / Unkown
HY-182038 TGF-β1/Smad3-IN-2 / Unkown
HY-19380 Ro-65-2299 Agonist / Unkown
HY-32351AS1 Calcifediol-13C5 monohydrate / Unkown
HY-N10508S Calcitroic acid-13C / Unkown
HY-RS03451 CYP27B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15634 Vdr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-10002S Calcitriol-13C3 Inhibitor 97.0% Unkown
HY-177795 5β-Cholanic acid-3,6-dione / Unkown
HY-180503 19-Nor-22-oxa-1a,25(OH)2-VD3 / Unkown
HY-32350S1 Ercalcitriol-d3 Activator / Unkown
HY-RS16287 Cyp27b1 Mouse Pre-designed siRNA Set A / Unkown
HY-107218 11-Hydroxysugiol Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vdr NCBI NCBI:7421