VDR - vitamin D receptor Gene

Also Known as NR1I1; PPP1R163

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7421

About VDR

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:47,841,537-47,904,994 (from NCBI)

This gene has 8 transcripts (splice variants), 462 orthologues, 18 paralogues and is associated with 3 phenotypes. Broad expression in small intestine (RPKM 24.6), duodenum (RPKM 24.1) and 14 other tissues.

Summary

This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of Other metabolic pathways, such as those involved in immune response and Cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]

VDR Products (8)

mRNA	Protein	Name
XM_047429500.1	XP_047285456.1	vitamin D3 receptor isoform X2
NM_001017535.2	NP_001017535.1	vitamin D3 receptor isoform VDRA
XM_024449178.2	XP_024304946.1	vitamin D3 receptor isoform X1
NM_001364085.2	NP_001351014.1	vitamin D3 receptor isoform VDRAx
NM_001374662.1	NP_001361591.1	vitamin D3 receptor isoform VDRA
NM_001017536.2	NP_001017536.1	vitamin D3 receptor isoform VDRB1
NM_000376.3	NP_000367.1	vitamin D3 receptor isoform VDRA
NM_001374661.1	NP_001361590.1	vitamin D3 receptor isoform VDRA

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11891224	GOA
contributes to DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17426122	GOA
enables bile acid nuclear receptor activity	IDA IDA: Inferred from direct assay	12016314	GOA
enables calcitriol binding	IDA IDA: Inferred from direct assay	10678179	GOA
enables calcitriol binding	IMP IMP: Inferred from mutant phenotype	28698609	GOA
enables lithocholic acid binding	IDA IDA: Inferred from direct assay	12016314	GOA
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	10678179	GOA
enables nuclear receptor activity	IMP IMP: Inferred from mutant phenotype	28698609	GOA
enables nuclear retinoid X receptor binding	IDA IDA: Inferred from direct assay	28698609	GOA
enables nuclear retinoid X receptor binding	IPI IPI: Inferred from physical interaction	17426122	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9632709	GOA
contributes to vitamin D response element binding	IDA IDA: Inferred from direct assay	17426122	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell morphogenesis	IMP IMP: Inferred from mutant phenotype	17223341	GOA
involved in decidualization	IEP IEP: Inferred from expression pattern	16720713	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20171278	GOA
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11891224	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16549446	GOA
involved in negative regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	17223341	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17426122	GOA
involved in nuclear receptor-mediated bile acid signaling pathway	IDA IDA: Inferred from direct assay	12016314	GOA
involved in phosphate ion transmembrane transport	IDA IDA: Inferred from direct assay	32354638	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17223341	GOA
involved in positive regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	17082781	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20171278	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17082781	GOA
involved in positive regulation of vitamin D 24-hydroxylase activity	IDA IDA: Inferred from direct assay	16549446	GOA
involved in positive regulation of vitamin D receptor signaling pathway	IDA IDA: Inferred from direct assay	20171278	GOA
involved in response to bile acid	IDA IDA: Inferred from direct assay	12016314	GOA
involved in retinoic acid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28698609	GOA
involved in vitamin D receptor signaling pathway	IDA IDA: Inferred from direct assay	16549446	GOA
involved in vitamin D receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28698609	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	17426122	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	22179700	GOA
located in chromatin	IDA IDA: Inferred from direct assay	12016314	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	16207705	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15589699	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	17426122	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VDR Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
427 a.a.

Protein Preferred Names	Protein Names
vitamin D3 receptor	1,25-dihydroxyvitamin D3 receptor nuclear receptor subfamily 1 group I member 1 protein phosphatase 1, regulatory subunit 163 vitamin D (1,25- dihydroxyvitamin D3) receptor

VDR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VDR	P11473	PTPN3	Homo sapiens	P26045	Pull Down	21119599
Intra	VDR	P11473	PTPN3	Homo sapiens	P26045	Anti Tag CoIP	21119599
Intra	VDR	P11473	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	27728806
Cross	VDR	P11473	Rxra	Mus musculus	P28700	Anti Tag CoIP	27728806
Intra	VDR	P11473	TRIP13	Homo sapiens	Q15645	Validated Y2H	25910212
Intra	VDR	P11473	TRIP13	Homo sapiens	Q15645	Y2H Array	25910212
Intra	VDR	P11473	TRIP13	Homo sapiens	Q15645	Y2H Bait-Prey Pool	25910212
Intra	VDR	P11473	TP53	Homo sapiens	P04637	Anti Bait CoIP	20227041
Intra	VDR	P11473	TP53	Homo sapiens	P04637	CH-IP	20227041
Intra	VDR	P11473	MED1	Homo sapiens	Q15648	Pull Down	9653119
Intra	VDR	P11473	EP300	Homo sapiens	Q09472	Y2H	21988832
Intra	VDR	P11473	EP300	Homo sapiens	Q09472	Anti Bait CoIP	20089040
Intra	VDR	P11473	NCOA1	Homo sapiens	Q15788	Pull Down	12403843
Intra	VDR	P11473	SNW1	Homo sapiens	Q13573	Far-WB	9632709
Intra	VDR	P11473	SNW1	Homo sapiens	Q13573	Confocal	12840015
Intra	VDR	P11473	SNW1	Homo sapiens	Q13573	Y2H	9632709
Intra	VDR	P11473	MEOX2	Homo sapiens	P50222	Validated Y2H	25910212
Intra	VDR	P11473	MEOX2	Homo sapiens	P50222	Y2H Array	25910212
Intra	VDR	P11473	MEOX2	Homo sapiens	P50222	Y2H Bait-Prey Pool	25910212
Intra	VDR	P11473	RXRA	Homo sapiens	P19793	EM	22179700
Cross	VDR	P11473	Ncoa6	Rattus norvegicus	Q9JLI4	Pull Down	10866662

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VDR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73543	Vitamin D Receptor/VDR Protein, Human (sf9, His)	P11473 (M1-S427)	≥ 90%, as determined by reducing SDS-PAGE.

VDR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81203	Vitamin D Receptor Antibody	IHC-P, IHC-F, ICC/IF	Human, Rat
HY-P85862	Vitamin D Receptor Antibody (YA5554)	WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Vitamin D Hydroxylation-Deficient Rickets, Type 1b	VDDR1B Vitamin D-Dependent Rickets Type 1b Vitamin D-Dependent Rickets, Type 1b 25-Hydroxyvitamin D3 Deficiency, Selective Pseudovitamin D3 Deficiency Rickets Due To 25-Hydroxylase Deficiency Rickets Due To Defect In Vitamin D 25-Hydroxylation Deficiency Rickets Vitamin D-Dependent 1b 25-Hydroxyvitamimn D3 Deficiency Selective 25-Hydroxyvitamin D(3) Deficiency Pseudovitamin D(3) Deficiency Rickets Due To 25-Hydroxylase Deficiency Selective 25-Hydroxyvitamin D(3) Deficiency Rickets Due To Defect In Vitamin D 25-Hydroxylation
Aggressive Periodontitis	Juvenile Periodontitis Periodontitis, Juvenile Prepubertal Periodontitis
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Hypocalcemia, Autosomal Dominant 1	Autosomal Dominant Hypocalcemia Autosomal Dominant Hypocalcemia 1 HYPOC1 Hypocalcemia, Autosomal Dominant Hypercalciuric Hypocalcemia Hypocalcemia, Autosomal Dominant, With Bartter Syndrome Familial Hypocalcemia Hypocalcemia, Familial Hypoc Adh Autosomal Dominant Hypoparathyroidism Familial Hypercalciuric Hypocalcemia Ad Hypocalcemia Autosomal Dominant Hypocalcemia With Bartter Syndrome Hypoparathyroidism - Autosomal Dominant Hypocalcemia
Rickets	Vitamin D Deficiency Active Rickets Hypovitaminosis D Nutritional Rickets Vitamin D Deficiency Disease Vitamin-D Deficiency Rickets Vitamin D Vitamin D-Dependent Rickets Avitaminosis D Infantile Osteomalacia Juvenile Osteomalacia
Hypercalciuria, Absorptive, 2	HCA2 Hypercalciuria, Absorptive, Susceptibility To Hypercalciuria, Absorptive Familial Idiopathic Hypercalciuria Hypercalciuria, Familial Idiopathic Hypercalciuria Absorptive 2 Hypercalciuria Familial Idiopathic Hypercalciuria, Absorptive, Type 2 Hypercalciuria
Hypercalcemia, Infantile, 1	HCINF1 Hypercalcemia, Idiopathic, Of Infancy Hypercalcemia Infantile Idiopathic Hypercalcemia Of Infancy Infantile Hypercalcemia Hypercalcemia, Infantile Hypercalcemia, Infantile, Type 1 Hypercalcemia
Hypervitaminosis D	Vitamin D Hyperalimentation
Lymphadenitis	Acute Lymphadenitis Chronic Lymphadenitis Chronic Adenitis Acute Adenitis Adenitis Inflammation Of Lymph Node Adenitis Nos Inflammation Of Gland Lymphatic Gland Inflammation Lymph Gland Inflammation Polyadenitis Chronic Adenitis Of Any Lymph Node Except Mesenteric Chronic Lymphadenitis Except Mesenteric Chronic Non-Specific Lymphadenitis
Rosacea	Erythematotelangiectatic Rosacea Papulopustular Rosacea Phymatous Rosacea Acne Roscea Acne, Erythematosa Granulomatous Rosacea Ocular Rosacea Acne Rosacea Hypertrophic Rosacea
Prostatitis
Skin Carcinoma	Skin Cancer Carcinoma Of Skin Ca - Skin Cancer Cancer Of Skin Malignant Neoplasm Of Skin Melanoma And Non-Melanoma Skin Cancer Skin Cancers Cancer, Skin
Rete Ovarii Adenoma	Adenoma Of Rete Ovarii
Calciphylaxis	Idiopathic Calciphylaxis
Scoliosis
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Turner Syndrome	Monosomy X Gonadal Dysgenesis Turner Type Ullrich-Turner Syndrome Bonnevie-Ullrich Syndrome Karyotype 45, X Genital Dwarfism, Turner Type Gonadal Dysgenesis Turner'S Syndrome Gonadal Dysgenesis - Turner Monosomy X Syndrome Xo Syndrome Genital Dwarfism 45, X Syndrome Bonnevie-Ulrich Syndrome Chromosome X Monosomy X Schereshevkii Turner Syndrome Turner Varny Syndrome 45,X Ts 45,X Syndrome 45,X/46,Xx Syndrome Turners Syndrome Gonadal Dysgenesis, 45,X X0 Syndrome
Nephrotic Syndrome, Type 20	NPHS20 Nephrotic Syndrome Type 20 Nephrotic Syndrome 20
Osteochondrosis	Osteochondritis Apophysitis Epiphysitis Osteochondritis Juvenilis Epiphyseal Necrosis Juvenile Osteochondrosis Of Tibial Tubercle
Urolithiasis
Osteomalacia	Adult Rickets
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Graves' Disease	Graves Disease Exophthalmic Goiter Basedow'S Disease Grave'S Disease Basedow Disease Toxic Diffuse Goiter Graves' Hyperthyroidism Parry Disease Autoimmune Hyperthyroidism Toxic Multinodular Goiter
Spondylosis	Lumbar Spondylosis With Myelopathy Lumbosacral Spondylosis Without Myelopathy Spondylogenic Compression Of Lumbar Spinal Cord Spondylogenic Compression Of Thoracic Spinal Cord Spondylosis With Myelopathy Thoracic Or Lumbar Spondylosis With Myelopathy
Hypophosphatemic Rickets, X-Linked Recessive	Hypophosphatemic Rickets X-Linked Recessive Hypophosphatemic Rickets XLRHR Hypophosphatemic Rickets Disorders Rickets Hypophosphatemic Rickets, Hypophosphatemic, X-Linked Recessive Familial Hypophosphatemic Rickets
Nephrolithiasis, Calcium Oxalate	Kidney Stones Calculus Of Kidney Kidney Calculi Nephrolithiasis Renal Calculi Calcium Oxalate Urolithiasis CAON Urolithiasis, Calcium Oxalate Calcium Oxalate Nephrolithiasis Kidney Stone Nephrolith Renal Calculus Urinary Stones Renal Stone Calculus, Kidney Calculus, Renal Renal Lithiasis Renal Stones Urolithiasis Renal Calculus Or Stone Stone In Kidney Nephritic Calculus Multiple Kidney Calculi Multiple Kidney Calculus Nephrolithiasis Nos Pelvic Nephrolithiasis Pelviolithiasis Pelvis Nephrolithiasis
Hyperphosphatemia
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculosis, Susceptibility To Tuberculoma Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Bone Resorption Disease	Bone Resorption
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Mouth Disease	Mouth Diseases Mouth Disorders
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Otosclerosis	Otospongiosis
Atrichia With Papular Lesions	Papular Atrichia APL Congenital Atrichia
Psoriasis
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases Cardiovascular Disease
Bone Remodeling Disease
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Primary Hyperparathyroidism	Familial Primary Hyperparathyroidism Hyperparathyroidism, Primary Hyperparathyroidism Primary Hypocalciuric Hypercalcemia, Familial, Type 1 Familial Benign Hypercalcemia Familial Hyperparathyroidism Parathyroid Enlargement
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Hand, Foot And Mouth Disease	Vesicular Stomatitis And Exanthem
Mineral Metabolism Disease	Mineral Metabolism Disorder Disorder Of Mineral Metabolism
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Parathyroid Adenoma	Adenoma Of Parathyroid Adenoma Of The Parathyroid Gland Parathyroid Gland Adenoma
Alopecia
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Osteonecrosis	Bone Necrosis Avascular Necrosis Of Bone Aseptic Necrosis Necrosis Of Bone Nos Aseptic Osteonecrosis Aseptic Necrosis Of Bone, Site Unspecified Aseptic Or Avascular Bone Necrosis Aseptic Necrosis Of Bone Necrotic Bone Necrotizing Bone Spontaneous Osteonecrosis Osteoradionecrosis
Dental Caries	Dental Caries Extending Into Pulp Dental Caries Of Smooth Surface Dental Caries Pit And Fissure Smooth Surface Dental Caries Dental Decay Carious Teeth Dental Cavity Saprodontia Teeth Decayed Tooth Caries Tooth Decay
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Syringomyelia	Hydromyelia
Plasmablastic Lymphoma	Pbl Immunoblastic Large-Cell Lymphoma
Rete Ovarii Benign Neoplasm
Periodontitis	Chronic Pericementitis Chronic Periodontitis
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Diabetes Mellitus	Diabetes
Hypophosphatemia	Vitamin D-Resistant Rickets Hereditary Hypophosphatemic Rickets Vdrr Vitamin D Resistant Rickets Hypophosphatemic Rickets, X-Linked Dominant Familial Hypophosphatemic Rickets
Infertility
Erythema Nodosum
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Beta-Thalassemia	Beta Thalassemia Cooley'S Anemia Mediterranean Anemia Beta Thalassemia Intermedia Erythroblastic Anemia Thalassemia, Hispanic Gamma-Delta-Beta Thalassemia Major Thalassemia Minor Beta-Plus-Thalassemia Thalassemia, Beta Beta Thalassemia Major Beta Thalassemia Minor Thalassemias, Beta- Microcytemia, Beta Type Thalassemia, Beta Type B-THAL Mediterranean Anaemia Beta Thalassaemia Syndrome Mediterranean Disease Beta Thalassaemia Disease
Secondary Hyperparathyroidism	Hyperparathyroidism Secondary Hyperparathyroidism, Secondary Secondary Hyperparathyroidism Nec
Pulmonary Tuberculosis	Tuberculosis, Pulmonary PTB Tuberculosis Pulmonary
Rectum Cancer	Malignant Neoplasm Of Rectum Rectal Cancer Cancer Of Rectum Carcinoma Of Rectum Carcinoma Of The Rectum Malignant Rectal Tumor Malignant Rectum Tumor Malignant Tumor Of Rectum Rectal Carcinoma Rectal Cancers Cancer, Rectal
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Insulin-Dependent Diabetes Mellitus Type 1 Diabetes T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Hepatocellular Clear Cell Carcinoma	Clear Cell Carcinoma Of The Liver Cells Hepatocellular Carcinoma, Clear Cell Type Clear Cell Hepatocellular Carcinoma
Hypoparathyroidism	Hypoparathyroidism, Idiopathic Parathyroid, Underactivity Of Syndrome With Hypoparathyroidism Deficiency Of Parathyroid Hormone Parathyroid Gland Insufficiency Parathyroid Insufficiency Hypoparathyroidism Due To Impaired Pth - [Parathyroid Hormone] Secretion
Renal Osteodystrophy	Renal Rickets Chronic Kidney Disease-Mineral And Bone Disorder
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Vitamin D Hydroxylation-Deficient Rickets, Type 1a	Vitamin D-Dependent Rickets, Type 1a Vitamin D-Dependent Rickets, Type 1 VDDR1A 25-Hydroxycholecalciferol-1-Hydroxylase Deficiency 1-Alpha-Hydroxylase Deficiency Vdd1 Pddr1a Pddr Ia Vitamin D-Dependent Rickets, Type I Vitamin D-Dependent Rickets Type 1a 1-Alpha, 25-Hydroxyvitamin D3 Deficiency, Selective Vitamin D Dependency, Type 1 Pseudovitamin D-Deficiency Rickets, Type Ia Rickets Vitamin D-Dependent 1a 1-Alpha 25-Hydroxyvitamin D3 Deficiency Selective Pddr Pseudovitamin D Deficiency Rickets Pseudovitamin D-Deficiency Rickets Type Ia Vitamin D Dependency Type 1
Parathyroid Gland Disease	Parathyroid Diseases Disease Of Parathyroid Glands Parathyroid Disease
Hyperparathyroidism	Hyperparathyroidism And Other Disorders Of Parathyroid Gland Parathyroid Hyperfunction Hpth - [Hyperparathyroidism] Parathyroid Gland Hyperfunction Parathyroid Glandular Hyperfunction
Williams-Beuren Syndrome	Williams Syndrome WBS Wms Deletion 7q11.23 Monosomy 7q11.23 Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb Fanconi Schlesinger Syndrome Beuren Syndrome Elfin Facies Syndrome Elfin Facies With Hypercalcemia Hypercalcemia-Supravalvar Aortic Stenosis Ws
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Vitamin D-Dependent Rickets	Vddr
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Intervertebral Disc Disease	Lumbar Disc Disease Intervertebral Disc Disorder IDD Lumbar Disc Herniation Lumbar Disc Degeneration Intervertebral Disc Disease, Susceptibility To Lumbar Disc Herniation, Susceptibility To Lumbar Disc Disease, Susceptibility To Intervertebral Disc Degeneration Discogenic Disease Discogenic Disorder Disorder Of Intervertebral Disc Intervertebral Disk Degeneration Intervertebral Disk Disease Ldd Ldh Lumbar Disc Degeneration, Susceptibility To Degeneration Of Lumbar Intervertebral Disc Intervertebral Disk Displacement
Dentinogenesis Imperfecta	Hereditary Opalescent Dentin Dentinogenesis Imperfecta Without Osteogenesis Imperfecta Dgi Capdepont Teeth Dgi Without Oi Di Non-Syndromic Dgi Non-Syndromic Dentinogenesis Imperfecta Opalescent Teeth Without Oi Opalescent Teeth Without Osteogenesis Imperfecta Opalescent Dentin
Phosphorus Metabolism Disease	Phosphorus Metabolism Disorders Disorder Of Phosphorus Metabolism Phosphorus Disorder Phosphorus Metabolism Disorder
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Vitamin D-Dependent Rickets, Type 2a	Hvdrr Generalized Resistance To 1,25-Dihydroxyvitamin D Hypocalcemic Vitamin D-Resistant Rickets VDDR2A Rickets, Hereditary Vitamin D-Resistant Vitamin D-Resistant Rickets With End-Organ Unresponsiveness To 1,25-Dihydroxycholecalciferol Pddr Iia Rickets-Alopecia Syndrome Rickets, Vitamin D-Resistant, Type Iia Vitamin D-Dependent Rickets Type 2a Vitamin D-Dependent Rickets, Type 2 Vitamin D-Dependent Rickets, Type 2a, With Or Without Alopecia Generalized 1,25-Dihydroxyvitamin D Pseudovitamin D-Deficiency, Type Iia Hereditary Vitamin D-Resistant Rickets Vddr Ii Vdrr Ii Vitamin D-Dependent Rickets Type Ii Vitamin D-Resistant Rickets Type Ii Rickets Vitamin D-Dependent 2a Pseudovitamin D-Deficiency Type Iia Rickets Hereditary Vitamin D-Resistant Type Iia Rickets Vitamin D-Dependent Rickets Type 2a With Or Without Alopecia Vitamin D-Dependent Rickets, Type Ii Familial Hypophosphatemic Rickets Hypophosphatemic Rickets, X-Linked Dominant
Uremia	Uremia Of Renal Origin
Nephrolithiasis	Kidney Stones Stone - Kidney/Ureter Kidney Calculi
Fabry Disease	Alpha-Galactosidase A Deficiency Anderson-Fabry Disease Angiokeratoma Corporis Diffusum Ceramide Trihexosidase Deficiency Fabry Disease, Cardiac Variant Fabry'S Disease Hereditary Dystopic Lipidosis Gla Deficiency FD Alpha Galactosidase Deficiency Deficiency Of Melibiase Angiokeratoma, Diffuse Angiokeratoma Diffuse Diffuse Angiokeratoma
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10002	Calcitriol	Agonist	99.94%	Unkown
HY-32351	Calcifediol		99.94%	Unkown
HY-10003	Alfacalcidol	Activator	99.96%	Unkown
HY-32339	Maxacalcitol	Activator	99.71%	Unkown
HY-32351A	Calcifediol monohydrate		99.98%	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Purity	Phase
HY-32344	Inecalcitol	98.44%	Phase 2
HY-32345	Elocalcitol	99.2%	Phase 2
HY-14863	Lunacalcipol	/	Phase 2
HY-32351S3	Calcifediol-d9	/	Phase 2
HY-B1844	Flucythrinate	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (60)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147337	MeTC7	Antagonist	98.50%	Unkown
HY-32343	Secalciferol	Activator	99.85%	Unkown
HY-12407	ZK168281	Antagonist	98.0%	Unkown
HY-76814	Calcitriol-d6	Activator	99.27%	Unkown
HY-32350	Ercalcitriol	Activator	99.71%	Unkown
HY-13332	Calcifediol-d6	Activator	99.09%	Unkown
HY-12398	TEI-9647	Agonist	99.10%	Unkown
HY-103053	PS121912	Inhibitor	96.40%	Unkown
HY-10002A	(1S)-Calcitriol		98.52%	Unkown
HY-12397	ZK159222	Antagonist	99.23%	Unkown
HY-12398A	TEI-9648	Inhibitor	99.24%	Unkown
HY-77278	25-Hydroxytachysterol3	Agonist	98.07%	Unkown
HY-15329	Maxacalcitol-d6	Activator	96.03%	Unkown
HY-32351S	Calcifediol-d3		98.96%	Unkown
HY-131492	Δ4-Dafachronic acid	Ligand	96.93%	Unkown
HY-RS15632	VDR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-131961	Triciferol		98.61%	Unkown
HY-N10508	Calcitroic acid	Agonist	85.0%	Unkown
HY-13294	Impurity C of Alfacalcidol	Activator	99.81%	Unkown
HY-15332	Alfacalcidol-d6	Activator	98.0%	Unkown
HY-32351AS	Calcifediol-d6 monohydrate		97.50%	Unkown
HY-13293	Impurity C of Calcitriol	Activator	99.84%	Unkown
HY-RS15633	Vdr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-154825	20-Hydroxyvitamin D3		≥98.0%	Unkown
HY-77274	Calcitriol Impurities D	Activator	95.18%	Unkown
HY-114310	VDR agonist 1		/	Unkown
HY-10002B	(1R,5Z)-Calcitriol	Control	/	Unkown
HY-119612	XCT0135908		/	Unkown
HY-10002AS	(1S)-Calcitriol-d3		/	Unkown
HY-10002AS2	(1S)-Calcitriol-d6		/	Unkown
HY-10002S1	Calcitriol-d3		/	Unkown
HY-10002S2	Calcitriol-d9		/	Unkown
HY-10003S	Alfacalcidol-d7	Activator	/	Unkown
HY-117182	LG190178		/	Unkown
HY-118970	LG190155		/	Unkown
HY-131492S	Δ4-Dafachronic Acid-d3	Ligand	/	Unkown
HY-149899	VDR agonist 2	Agonist	/	Unkown
HY-15364	19-nor-1α,25-Dihydroxyvitamin D3	Ligand	/	Unkown
HY-161778	ZG-126		/	Unkown
HY-163947	UG-480	Modulator	/	Unkown
HY-166525S	24R-Calcipotriol-d4	Activator	/	Unkown
HY-170975	UG-650	Ligand	/	Unkown
HY-172087	VDR agonist 3	Agonist	/	Unkown
HY-173393	LXRα agonist 1	Agonist	/	Unkown
HY-178328	VDR agonist 4		/	Unkown
HY-178336	AC-340		/	Unkown
HY-179431	VDR ligand-1	Agonist	/	Unkown
HY-181486	VDR agonist 5	Agonist	/	Unkown
HY-182038	TGF-β1/Smad3-IN-2		/	Unkown
HY-19380	Ro-65-2299	Agonist	/	Unkown
HY-32351AS1	Calcifediol-13C5 monohydrate		/	Unkown
HY-N10508S	Calcitroic acid-13C		/	Unkown
HY-RS03451	CYP27B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15634	Vdr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-10002S	Calcitriol-13C3	Inhibitor	97.0%	Unkown
HY-177795	5β-Cholanic acid-3,6-dione		/	Unkown
HY-180503	19-Nor-22-oxa-1a,25(OH)2-VD3		/	Unkown
HY-32350S1	Ercalcitriol-d3	Activator	/	Unkown
HY-RS16287	Cyp27b1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-107218	11-Hydroxysugiol	Modulator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VDR	VGNC	VGNC:36784
Canis familiaris	VDR	VGNC	VGNC:48249
Macaca mulatta	VDR	VGNC	VGNC:78764
Mus musculus	VDR	MGD	MGI:103076
Rattus norvegicus	VDR	RGD	RGD:3959
Felis catus	VDR	VGNC	VGNC:66935
Others	VDR	NCBI