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Cat. No.: HY-169264

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SJYHJ-026

SJYHJ-026 (compound 37) is a pregnane X receptor (PXR) PROTAC degrader with the DC₅₀ of 86.6 nM and maximal degradation of 66.4%. SJYHJ-026 shows cell cytotoxic aganist SNU-C4 HiBiT-PXR KI cells with the IC₅₀ values of 97.4 μM (24 h) and 99.5 μM (72 h).
(Pink: Pregnane X Receptor (PXR) ligand (HY-169277); Blue: VHL ligand (HY-125845); Black: linker (HY-43048)).

For research use only. We do not sell to patients.

Formula: C₆₀H₈₄N₈O₁₁S
Molecular Weight:1125.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SJYHJ-026 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

SJYHJ-026 (compound 37) is a pregnane X receptor (PXR) PROTAC degrader with the DC₅₀ of 86.6 nM and maximal degradation of 66.4%. SJYHJ-026 shows cell cytotoxic aganist SNU-C4 HiBiT-PXR KI cells with the IC₅₀ values of 97.4 μM (24 h) and 99.5 μM (72 h)^[1]. (Pink: Pregnane X Receptor (PXR) ligand (HY-169277); Blue: VHL ligand (HY-125845); Black: linker (HY-43048)).

All PROTACs Isoforms :

Chemical Information

Molecular Weight 1125.42
Formula C₆₀H₈₄N₈O₁₁S
SMILES

O=C(NC1=CC(C(C)(C)C)=CC=C1O[C@@H](CC)CCC)C2=C(N(N=N2)C3=CC(OC)=C(C=C3OC)OCCCCCCOCCOCC(N[C@H](C(N4[C@@H](C[C@H](C4)O)C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)=O)C(C)(C)C)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huber AD, et al. First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy. J Med Chem. 2024;67(20):18549-18575. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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SJYHJ-026

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SJYHJ-026 Related Classifications

HY-169264 Related Classifications