SJYHJ-026

SJYHJ-026 (dose-response range; 24 h) potently induces degradation of endogenous PXR in SNU-C4 HiBiT-PXR KI cells with a DC₅₀ of 86.6 nM and 66.4% maximal degradation, and exhibits no significant cytotoxicity at concentrations up to 30 μM^[1].
SJYHJ-026 (dose-response range; 24 h) potently induces degradation of endogenous PXR in SNU-C4 3xFLAG-PXR KI cells with a DC₅₀ of ~50 nM and ~80% maximal degradation, as measured by western blot^[1].
SJYHJ-026 (10 μM; 24 h) exhibits high specificity for PXR, with no off-target protein degradation detected in SNU-C4 cells treated with 10 μM for 24 h as measured by TMT-MS^[1].
SJYHJ-026 does not degrade CAR, VDR, FXR, LXRα, or LXRβ, demonstrating selectivity for PXR among related nuclear receptors^[1].
SJYHJ-026 binds to the PXR ligand binding pocket with higher affinity than most tested PROTAC analogs, supporting its potent PXR degradation activity^[1].