Lomibuvir (Standard)
Lomibuvir (Standard) is the analytical standard of Lomibuvir. This product is intended for research and analytical applications. Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis.
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- Pureté : 98%
- CAS No.: 1026785-55-6
- Formule: C25H35NO4S
- Masse moléculaire:445.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
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HY-75800
LomibuvirNS5B Polymerase/RdRp Inhibitor -
HY-10241
SimeprevirHCV NS3/4A Inhibitor -
HY-13997
OmbitasvirHCV NS5A Inhibitor -
HY-109571
HZ-1157HCV NS3/4A Inhibitor -
HY-13997R
Ombitasvir (Standard)HCV NS5A Inhibitor -
HY-10241R
Simeprevir (Standard)Reference Standard -
HY-10241A
Simeprevir sodiumHCV NS3/4A Inhibitor
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 1026785-55-6
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Masse moléculaire 445.61
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Formule C25H35NO4S
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SMILES
O=C(C1=C(N([C@@H]2CC[C@@H](O)CC2)C([C@H]3CC[C@H](C)CC3)=O)C=C(C#CC(C)(C)C)S1)O
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Synonyms
VX-222 (Standard)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Yi G, Deval J, et al. Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir. Antimicrob Agents Chemother. 2012;56(2):830-837. [Content Brief]
[2]. Li P, Dorsch W, et al. Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates. ACS Med Chem Lett. 2017;8(2):251-255. Published 2017 Jan 31. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lomibuvir (Standard) Related Classifications
HY-75800R Related Classifications
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