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Cat. No.: HY-124305

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ML395

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

ML395 is a potent and selective allosteric inhibitor of phospholipase D2 with antiviral activity. The cellular PLD1 IC50 value of ML395 exceeds 30,000 nM, while its cellular PLD2 IC50 value is 360 nM. ML395 shows excellent pharmacokinetic characteristics in vitro and physiochemical properties superior to other reported phospholipase inhibitors. ML395 shows interesting antiviral activity in cell-based assays against multiple influenza virus strains (H1, H3, H5, and H7).

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CAS No.: 1638957-17-1
Formule: C₂₆H₂₉N₅O₂
Masse moléculaire:443.54

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

ML395 Chemical Structure

CAS No.: 1638957-17-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

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Chemical Information

CAS No. 1638957-17-1
Masse moléculaire 443.54
Formule C₂₆H₂₉N₅O₂
SMILES

O=C(C1=CC=C2C=CC=CC2=C1)NCCN(CC3)CCC3(N(CC4=CC=CN=C4)CN5)C5=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Am J Orthod Dentofacial Orthop

Force threshold-dependent modulation of root resorption via the Nrf2/Keap1/p62 antioxidant pathway during orthodontic tooth movement. [Abstract]

2025 Dec 4:S0889-5406(25)00481-0. PMID: 41342829

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Discovery of a highly selective PLD2 inhibitor (ML395): a new probe with improved physiochemical properties and broad-spectrum antiviral activity against influenza strains

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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