NLRP3-IN-9
NLRP3-IN-9 is a potent NLRP3 inhibitor. NLRP3-IN-9 inhibits IL-1β release. NLRP3-IN-9 reduces inflammation and mechanical hyperalgesia. NLRP3-IN-9 has the potential for the research of gout.
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- CAS No.: 2768759-64-2
- Formule: C16H19N2NaO5S
- Masse moléculaire:374.39
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
NLRP3 |
In Vitro
NLRP3-IN-9 (compound 4b) (0.01-3 µM) inhibits IL-1β release in a dose-dependent manner in ATP (5 mM) and LPS (1 µg/mL)-induced macrophages[1].
NLRP3-IN-9 (1 µM; 15 min) inhibits NLRP3 inflammasome oligomerization[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Macrophages
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Concentration:1 µM
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Incubation Time:15 min
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Result:Inhibited teh expression of IL-1β P17, Casp-1 p10 peotein levelwith the ATP (5 mM) and LPS (1 µg/mL)-induced in the supernatant of the cultures, without affecting the intracellular levels of their precursors.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3-4 month old male and female C57BL/6J WT and NLRP3-KO mice[1]
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Dosage:3, 10 mg/kg
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Administration:I.p.
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Result:Reduced paw swelling by 40% in males and 33% in females at 3 mg/kg, and 66% in males and 52% in females at 10 mg/kg in WT mouse.
Chemical Information
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CAS No. 2768759-64-2
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Masse moléculaire 374.39
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Formule C16H19N2NaO5S
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SMILES
O=C(N([Na])S(C1=CC(C(C)(O)C)=CO1)(=O)=O)NC2=CC(C)=CC(C)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NLRP3-IN-9 Related Classifications
HY-146802 Related Classifications
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