Pepticinnamin E
Pepticinnamin E is a Farnesyltransferase (FTase) inhibitor (IC50=42 µM). Pepticinnamin E can be used in cancer and malaria research.
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- CAS No.: 147317-36-0
- Formule: C49H54ClN5O10
- Masse moléculaire:908.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
IC50: 42 µM (Farnesyltransferase)[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LNCaP | IC50 |
>10 μM
Compound: 1
|
Cytotoxicity against drug resistant human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
Cytotoxicity against drug resistant human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
|
[PMID: 38591246] |
| LNCaP | IC50 |
>10 μM
Compound: 1
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Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
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[PMID: 38591246] |
| LNCaP C4-2B | IC50 |
>10 μM
Compound: 1
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Cytotoxicity against drug resistant human LNCaP C4-2B cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
Cytotoxicity against drug resistant human LNCaP C4-2B cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
|
[PMID: 38591246] |
| LNCaP C4-2B | IC50 |
>10 μM
Compound: 1
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Cytotoxicity against human LNCaP C4-2B cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
Cytotoxicity against human LNCaP C4-2B cells assessed as inhibition of cell growth incubated for 72 hrs by CellTox Green cytotoxicity assay
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[PMID: 38591246] |
Chemical Information
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CAS No. 147317-36-0
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Masse moléculaire 908.43
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Formule C49H54ClN5O10
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SMILES
O=C([C@@H](N(C)C([C@@H](N(C([C@H](NC(/C=C/C1=CC=CC=C1/C=C\CCC)=O)CC2=CC=C(C=C2)O)=O)C)CC3=CC=C(C(O)=C3Cl)OC)=O)CC4=CC=CC=C4)OC[C@@H](N5)C(NCC5=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Hinterding K, et al. Synthesis and In Vitro Evaluation of the Ras Farnesyltransferase Inhibitor Pepticinnamin E. Angew Chem Int Ed Engl. 1998 May 18;37(9):1236-1239. [Content Brief]
[2]. Santa Maria KC, et al. Targeted Rediscovery and Biosynthesis of the Farnesyl-Transferase Inhibitor Pepticinnamin E. Chembiochem. 2019 Jun 3;20(11):1387-1393. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pepticinnamin E Related Classifications
HY-124205 Related Classifications
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