PI4K-IN-3
PI4K-IN-3 (Compound 27) is an orally active PI4K inhibitor with an IC50 of 1.9 nM for Plasmodium vivax PI4K. PI4K-IN-3 has no hERG channel inhibition and mammalian cytotoxicity. PI4K-IN-3 has significant selectivity against the human MINK1 and MAP4K4 kinases but with low selectivity against human PI3Kα and PI4Kβ. PI4K-IN-3 has potent antimalarial activity and significantly reduces parasitaemia in NSG mice mouse models of Plasmodium falciparum malaria.
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- Formule: C25H24N4O2
- Masse moléculaire:412.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform Parasite
MoreVoir tous les produits spécifiques à Isoform MAP4K
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Activité biologique
|
MINK1/MAP4K6 >10 μM (IC50) |
MAP4K4 >10 μM (IC50) |
PvPI4K 1.9 nM (IC50) |
Plasmodium |
PI4KB 0.13 μM (IC50) |
PI3Kα 0.07 μM (IC50) |
Chemical Information
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Masse moléculaire 412.48
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Formule C25H24N4O2
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SMILES
OC(C)(C1=CC=C(C2=C3C(C=CC(C4=CC(CC(NC)=O)=CC=C4)=N3)=NC=C2)C=N1)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI4K-IN-3 Related Classifications
HY-178775 Related Classifications
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