Polygalacturonic acid
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Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity.
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- Pureté: 99.58%
- CAS No.: 25990-10-7
- Formule: (C6H10O7)x
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Polygalacturonic acid can be used to format a durable hydrogel, to prolong the effect of drugs. Polygalacturonic acid hydrogel/hyaluronate, conjugated Ibuprofen (HY-78131) for example, prevents epidural fibrosis, the severe scar tissue adhesion of laminectomized male adult rats, and increases the efficiency of local inflammation control and reduces the side-effect of Ibuprofen[1].
Polygalacturonic acid hydrogel/hyaluronate (PGA-HA) (2%, 200 μL; 24 h) shows low cytotoxicity on L929 fibroblasts[1].
Polygalacturonic acid (PGA) preparing (Ag-PGA/HA)-PVA nanoparticles, shows anti-bacterial activity against gram-positive bacterial strains; Bacillus Subtilis and Staphylococcus Aureus, as well as gram-negative bacterial strain; Escherichia Coli[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Full thickness wound model in albino rats (60-day-old, 180 g)[2]
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Dosage:Ag-Polygalacturonic acid/hyaluronic acid nanoparticles
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Administration:Applied on dorsal muscle fascia; cleaned the wound daily with alcohol; for 14 days
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Result:Resulted no sign of abscess formation or hypertrophic scars both in the early phase; 5th day or in the final phase; 14th day, respectively.
Showed significant wound healing from day 8 while treated with (Ag-PGA/HA)-PVA nanofiber and blank (PGA/HA)-PVA nanofiber and induced epithelization on day 14.
Chemical Information
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CAS No. 25990-10-7
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Appearance Solid
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Formule (C6H10O7)x
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Color Off-white to light yellow
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SMILES
O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O.[x]
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Synonyms
Galacturonic acid polymer
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
0.1 M NaOH : 10 mg/mL (ultrasonic and warming and adjust pH to 11 with NaOH and heat to 60°C)
H2O : < 0.1 mg/mL (insoluble)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Lin CY, et al. Ibuprofen-conjugated hyaluronate/polygalacturonic acid hydrogel for the prevention of epidural fibrosis. J Biomater Appl. 2016 May;30(10):1589-600. [Content Brief]
[2]. El-Aassar MR, et al. Wound healing of nanofiber comprising Polygalacturonic/Hyaluronic acid embedded silver nanoparticles: In-vitro and in-vivo studies. Carbohydr Polym. 2020 Jun 15;238:116175. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Polygalacturonic acid Related Classifications
HY-N6613 Related Classifications
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