SAR156497
SAR156497 (compound 47) is an Aurora inhibitor, with IC50 values of 0.6 nM and 1 nM for Aurora A and Aurora B, respectively. SAR156497 can also inhibit PDE3, with IC50 value of 4 μM. SAR156497 can be used in anticancer research.
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- CAS No.: 1256137-14-0
- Formule: C27H24N4O4
- Masse moléculaire:468.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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PDE3 4 μM (IC50) |
Aurora A 0.6 nM (IC50) |
Aurora B 1 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
3.714 μM
Compound: SAR156497
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Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
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[PMID: 28818446] |
| HEK293 | IC50 |
5.864 μM
Compound: SAR156497
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Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
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[PMID: 28818446] |
| HeLa | IC50 |
0.00611 μM
Compound: SAR156497
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
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[PMID: 28818446] |
| HeLa | IC50 |
67 nM
Compound: 47
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Antiproliferative activity against human HeLa cells assessed as 14C-thymidine incorporation by Micro-Beta radioactivity counting analysis
Antiproliferative activity against human HeLa cells assessed as 14C-thymidine incorporation by Micro-Beta radioactivity counting analysis
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[PMID: 25369539] |
| PBMC | IC50 |
>10 μM
Compound: 47
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Cytotoxicity against human hematological tumor PBMC assessed as viability after 96 hrs by MTS assay
Cytotoxicity against human hematological tumor PBMC assessed as viability after 96 hrs by MTS assay
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[PMID: 25369539] |
| PC-3 | IC50 |
12.58 μM
Compound: SAR156497
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Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
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[PMID: 28818446] |
Chemical Information
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CAS No. 1256137-14-0
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Masse moléculaire 468.50
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Formule C27H24N4O4
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SMILES
O=C1C([C@@H](C2=CC(OC3=NC4=CC=CC=C4N3)=CC=C2)C5=CN6)=C(CCC1)NC5=C6C(OCC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SAR156497 Related Classifications
HY-12476 Related Classifications
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