Y502-3888
Y502-3888 is a c-Myc inhibitor. Y502-3888 binds to the c-Myc G4 structure, inhibits c-Myc transcription, and downregulates c-Myc expression at both mRNA and protein levels. Y502-3888 inhibits the viability of myeloma cells and induces cell apoptosis. Y502-3888 can be used for the research of multiple myeloma.
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- CAS No.: 828292-11-1
- Formule: C19H18N6O3S
- Masse moléculaire:410.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
Y502-3888 (1-30 μM; 48 h) potently and selectively inhibits the viability of human multiple myeloma RPMI 8226 and U266 cells, with IC50 values of 12.67 μM and 7.03 μM, respectively, and minimal toxicity to non-malignant HEK293T cells[1].
Y502-3888 (5-20 μM; 48 h) dose-dependently induces apoptosis in human multiple myeloma U266 cells, with increasing proportions of early and late apoptotic cells at concentrations of 5, 10, and 20 μM[1].
Y502-3888 (5-20 μM; 48 h) dose-dependently downregulates c-Myc protein expression in human multiple myeloma U266 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human multiple myeloma U266 cells
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Concentration:5, 10 and 20 μM
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Incubation Time:48 h
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Result:Induced dose-dependent increases in apoptotic cell populations.Resulted in 8.68% early apoptotic and 15.4% late apoptotic cells at 5 μM.
Resulted in 16.2% early apoptotic and 26.2% late apoptotic cells at 10 μM.
Resulted in 24.9% early apoptotic and 57.0% late apoptotic cells at 20 μM.
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Cell Line:Human multiple myeloma U266 cells
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Concentration:5, 10 and 20 μM
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Incubation Time:48 h
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Result:Reduced c-Myc protein levels in a dose-dependent manner.
Caused statistically significant reductions in c-Myc protein levels at 10 μM and 20 μM relative to control cells.
Markedly decreased c-Myc protein levels at 20 μM.
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Cell Line:Human multiple myeloma U266 cells, CA46 Burkitt's lymphoma cells
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Concentration:5, 10 and 20 μM
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Incubation Time:48 h
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Result:Reduced c-Myc mRNA levels in U266 cells in a dose-dependent manner, with expression reduced to ~50% of control at 20 μM.
Dose-dependently suppressed Exon 1 c-Myc mRNA levels in CA46 cells, with minimal effect on Exon 2 levels.
Chemical Information
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CAS No. 828292-11-1
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Masse moléculaire 410.45
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Formule C19H18N6O3S
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SMILES
CCN(C(C1=C(C2=C(S1)N=CN3N=C(N=C23)C4=CC=CC=C4[N+]([O-])=O)C)=O)CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Y502-3888 Related Classifications
HY-181234 Related Classifications
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