2370913-42-9
Chemical Structure
Inixaciclib
Synonym(s): NUV-422
- CAS No.: 2370913-42-9
- Formula:C26H30F2N6O
- Molecular Weight:480.55
IUPAC Name: 5-fluoro-4-(8-fluoro-4-isopropyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-N-(5-(1-methylpiperidin-4-yl)pyridin-2-yl)pyrimidin-2-amine
InChIKey: YZSCPLGKKMSBMV-UHFFFAOYSA-N
SMILES: CN1CCC(C2=CN=C(NC3=NC=C(F)C(C4=CC(F)=C(OCCN5C(C)C)C5=C4)=N3)C=C2)CC1
Biological Activity: Inixaciclib (NUV-422) is a blood-brain barrier-penetrant inhibitor of CDK2, CDK4 and CDK6. Inixaciclib inhibits cancer cell growth. Inixaciclib induces anti-tumor activity in xenograft models of glioblastoma, CDK4/CDK6 inhibitor-resistant HR+ HER2- metastatic breast cancer, and anti-androgen-resistant prostate cancer. Inixaciclib can be used for the research of relapsed or metastatic castration-resistant prostate cancer[1].
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Inixaciclib | 99.93% | Inixaciclib (NUV-422) is a blood-brain barrier-penetrant inhibitor of CDK2, CDK4 and CDK6. Inixaciclib inhibits cancer cell growth. Inixaciclib induces anti-tumor activity in xenograft models of glioblastoma, CDK4/CDK6 inhibitor-resistant HR+ HER2- metastatic breast cancer, and anti-androgen-resistant prostate cancer. Inixaciclib can be used for the research of relapsed or metastatic castration-resistant prostate cancer. | ||||||||||||||||||||
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Keywords
