2769053-56-5
Chemical Structure
KDS12025
- CAS No.: 2769053-56-5
- Formula:C16H20N2O
- Molecular Weight:256.34
InChIKey: NTVVWXLYDMNTSN-UHFFFAOYSA-N
SMILES: CNC(C=C1)=CC=C1NCCC2=C(C=CC=C2)OC
Biological Activity: KDS12025 is a blood-brain barrier-permeable, orally active H2O2-decomposing peroxidase enhancer. KDS12025 enhances the H2O2-decomposing pseudoperoxidase activity of Hb without altering oxygen transport function, and reduces intracellular H2O2 load. KDS12025 reduces abnormal H2O2 levels and inhibits the production of COL1. KDS12025 restores cerebral blood flow, maintains neuronal excitability, membrane properties, synaptic connections and corticospinal tract fibers, reduces cerebral edema and exerts neuroprotective effects. KDS12025 improves motor function and overall neurological function. KDS12025 can be used in the research of ischemic stroke, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, aging-related neurodegenerative diseases and rheumatoid arthritis[1][2].
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KDS12025 | KDS12025 is a blood-brain barrier-permeable, orally active H2O2-decomposing peroxidase enhancer. KDS12025 enhances the H2O2-decomposing pseudoperoxidase activity of Hb without altering oxygen transport function, and reduces intracellular H2O2 load. KDS12025 reduces abnormal H2O2 levels and inhibits the production of COL1. KDS12025 restores cerebral blood flow, maintains neuronal excitability, membrane properties, synaptic connections and corticospinal tract fibers, reduces cerebral edema and exerts neuroprotective effects. KDS12025 improves motor function and overall neurological function. KDS12025 can be used in the research of ischemic stroke, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, aging-related neurodegenerative diseases and rheumatoid arthritis. | |||||||||||||||||||||
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References
- [1]. Lee JH, et al. Oxidative stress-induced astrocytic collagen biosynthesis drives glial barrier formation and neuronal death in ischemic stroke. Cell metabolism. 2026 Jul 07;38(7):1404-1424.e8.
- [2]. Won W, et al. Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases. Signal transduction and targeted therapy. 2025 Aug 22;10(1):270.
