Cat. No.: HY-186316

KDS12025

Name: KDS12025
Brand: MedChemExpress
SKU: HY-186316
Price: 345.00 USD
Availability: InStock
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KDS12025 is a blood-brain barrier-permeable, orally active H₂O₂-decomposing peroxidase enhancer. KDS12025 enhances the H₂O₂-decomposing pseudoperoxidase activity of Hb without altering oxygen transport function, and reduces intracellular H₂O₂ load. KDS12025 reduces abnormal H₂O₂ levels and inhibits the production of COL1. KDS12025 restores cerebral blood flow, maintains neuronal excitability, membrane properties, synaptic connections and corticospinal tract fibers, reduces cerebral edema and exerts neuroprotective effects. KDS12025 improves motor function and overall neurological function. KDS12025 can be used in the research of ischemic stroke, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, aging-related neurodegenerative diseases and rheumatoid arthritis.

For research use only. We do not sell to patients.

Purity : 99.74%
CAS No.: 2769053-56-5
Formula: C₁₆H₂₀N₂O
Molecular Weight:256.34

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

KDS12025 Chemical Structure

CAS No.: 2769053-56-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Oxidative StressAβ/Tau/α-Synuclein AggregationOthers

Oxidative Stress

KDS12025 significantly protects primary cortical neurons against astrocyte-mediated in vitro neurotoxicity induced by H₂O₂^[1].
KDS12025 (1 μM; 30 min) potently enhances the H₂O₂-decomposing pseudoperoxidase activity of purified hemoglobin, with an EC₅₀ of 0.04 μM, and effectively achieves H₂O₂ decomposition even at extremely low Hb concentrations^[2].

Oxidative Stress

Aβ/Tau/α-Synuclein Aggregation

KDS12025 (10 μM; 24 h) effectively reduces H₂O₂ levels induced by Aβ, putrescine and 6-OHDA (HY-B1081) in primary cultured hippocampal astrocytes, with an EC₅₀ of 0.5 μM, and its antioxidant effect depends on Hbβ in astrocytes^[2].

Others

KDS12025 binds strongly to the proximal heme site of the hemoglobin β subunit with a binding energy of −16.5 kcal/mol, thereby enhancing the pseudoperoxidase activity of Hb^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

OthersOxidative StressInnate ImmunityCytokines & Chemokines

Others

KDS12025 (0.001-10 mg/kg/day; i.p., oral ad libitum; once daily; 3 consecutive days) exhibits potent neuroprotective effects in a mouse ischemic stroke model, with an IC₅₀ of 0.0027 mg/kg/day for motor function recovery, reduces pathological remodeling, preserves neuronal function, and retains efficacy when administered up to 2 days post-stroke^[1].
KDS12025 (1 mg/kg/day; p.o.; ad libitum in drinking water; 4 weeks) fully restores motor function and reverses Parkinson's disease-related pathology in A53T α-synuclein mice, with efficacy dependent on both astrocytic and neuronal Hbβ^[2].
KDS12025 (0.1-1 mg/kg/day; p.o.; ad libitum in drinking water; 22 months) increases median survival by ~14%, restores locomotor function, prevents neuronal loss, reverses astrocytic atrophy, and restores astrocytic Hb_β levels in aging C57BL/6J mice^[2].

Oxidative Stress

KDS12025 (0.1-10 mg/kg/day; i.p., p.o.; daily, ad libitum in drinking water; 7 days, 2 weeks, 16 days) potently reverses Alzheimer's disease-related memory impairment, neurodegeneration, astrogliosis, oxidative stress, and neuronal dysfunction in APP/PS1 mice, with efficacy dependent on astrocytic Hbβ^[2].

Innate Immunity

Cytokines & Chemokines

KDS12025 (1 mg/kg/day) mitigates rheumatoid arthritis pathology and systemic inflammation in collagen-induced arthritis mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

APP/PS1 mice (10-18 months old, both sexes)^[2]
Dosage:

3 mg/kg/day; 10 mg/kg/day; 0.1 mg/kg/day
Administration:

i.p.; daily; 16 days, 7 days; p.o.; ad libitum in drinking water; 2 weeks, 16 days
Result:

Improved memory impairment.
Reduced hippocampal reactive astrocyte (GFAP) and microglia (Iba1) levels.
Reversed astrogliosis.
Normalized aberrant tonic GABA currents.
Restored astrocytic hemoglobin β (Hbβ) levels.
Reduced oxidative stress marker 8-OHdG levels.
Normalized astrocytic GABA levels.
Restored neuronal spike probability.
Abolished all effects following astrocytic Hbβ gene silencing.

Animal Model:

A53T α-synuclein overexpression mice^[2]
Dosage:

1 mg/kg/day
Administration:

p.o.; ad libitum in drinking water; 4 weeks
Result:

Rescued motor impairment.
Reversed tyrosine hydroxylase (TH)-positive dopaminergic neuronal loss.
Reduced astrogliosis.
Normalized abnormally elevated astrocytic GABA levels.
Restored astrocytic and neuronal Hbβ levels.
Partially abolished effects following either astrocytic or neuronal Hbβ gene silencing.

Animal Model:

C57BL/6J mice (14 months old, female)^[2]
Dosage:

0.1 mg/kg/day; 1 mg/kg/day
Administration:

p.o.; ad libitum in drinking water; 22 months
Result:

Increased median survival by ~14% in both dose groups.
Enabled 46.7% of female mice to survive to 31 months when all control mice had died.
Restored locomotor function in 26-month-old mice to levels comparable to 12-month-old mice.
Prevented neuronal loss in the hippocampal CA1 region.
Preserved TH-positive dopaminergic neurons in the substantia nigra pars compacta.
Reversed astrocytic atrophy, restoring astrocytic arborization to 18-month-old control levels.
Restored reduced astrocytic Hbβ levels to exceed those in 18-month-old mice.

Related Protocols :

Chemical Information

CAS No. 2769053-56-5
Appearance Oil
Molecular Weight 256.34
Formula C₁₆H₂₀N₂O
Color Yellow to brown
SMILES

CNC(C=C1)=CC=C1NCCC2=C(C=CC=C2)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (390.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.9011 mL

19.5053 mL

39.0107 mL

5 mM

0.7802 mL

3.9011 mL

7.8021 mL

10 mM

0.3901 mL

1.9505 mL

3.9011 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (286 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lee JH, et al. Oxidative stress-induced astrocytic collagen biosynthesis drives glial barrier formation and neuronal death in ischemic stroke. Cell metabolism. 2026 Jul 07;38(7):1404-1424.e8.

[2]. Won W, et al. Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases. Signal transduction and targeted therapy. 2025 Aug 22;10(1):270.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.9011 mL	19.5053 mL	39.0107 mL	97.5267 mL
	5 mM	0.7802 mL	3.9011 mL	7.8021 mL	19.5053 mL
	10 mM	0.3901 mL	1.9505 mL	3.9011 mL	9.7527 mL
	15 mM	0.2601 mL	1.3004 mL	2.6007 mL	6.5018 mL
	20 mM	0.1951 mL	0.9753 mL	1.9505 mL	4.8763 mL
	25 mM	0.1560 mL	0.7802 mL	1.5604 mL	3.9011 mL
	30 mM	0.1300 mL	0.6502 mL	1.3004 mL	3.2509 mL
	40 mM	0.0975 mL	0.4876 mL	0.9753 mL	2.4382 mL
	50 mM	0.0780 mL	0.3901 mL	0.7802 mL	1.9505 mL
	60 mM	0.0650 mL	0.3251 mL	0.6502 mL	1.6254 mL
	80 mM	0.0488 mL	0.2438 mL	0.4876 mL	1.2191 mL
	100 mM	0.0390 mL	0.1951 mL	0.3901 mL	0.9753 mL

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KDS12025