3026728-28-6
Chemical Structure
HDAC-IN-51
- No. CAS: 3026728-28-6
- Formula:C27H24N4O2
- Molecular Weight:436.51
IUPAC Name: N-(2-aminophenyl)-5-(2,3-diphenylpropanamido)picolinamide
InChIKey: FUOLFAHJLGZFME-UHFFFAOYSA-N
SMILES: NC1=CC=CC=C1NC(C2=NC=C(C=C2)NC(C(C3=CC=CC=C3)CC4=CC=CC=C4)=O)=O
Biological Activity: HDAC-IN-51 is a potent histone deacetylase (HDAC) inhibitor with IC50 values of 0.32, 0.353, 0.431, 0.515, and 85.4 μM for HDAC10, HDAC1, HDAC2, HDAC3 and HDAC11, respectively. HDAC-IN-51 induces cell cycle arrest and apoptosis, modulating cell cycle-/apoptosis-related miRNAs expression. HDAC-IN-51 can be used in research of cancer[1].
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HDAC-IN-51 | HDAC-IN-51 is a potent histone deacetylase (HDAC) inhibitor with IC50 values of 0.32, 0.353, 0.431, 0.515, and 85.4 μM for HDAC10, HDAC1, HDAC2, HDAC3 and HDAC11, respectively. HDAC-IN-51 induces cell cycle arrest and apoptosis, modulating cell cycle-/apoptosis-related miRNAs expression. HDAC-IN-51 can be used in research of cancer. | |||||||||||||||||||||
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Keywords
