52617-37-5
Chemical Structure
Ponicidin
Synonym(s): Rubescensine B
- CAS No.: 52617-37-5
- Formula:C20H26O6
- Molecular Weight:362.42
IUPAC Name: (1S,4S,5S,6aS,8S,9S,9aR,13S,14R)-8,9,13-trihydroxy-10,10-dimethyl-16-methylenedecahydro-1H,6aH,8H-1,5,8,4-(epipropane[1,1,1,3]tetrayl)oxocino[3,2-j]isochromen-15-one
InChIKey: WHRDRHNMTIXZNY-AMOJAPPFSA-N
SMILES: O[C@]12[C@]3(C4=O)[C@]5([H])C6([C@](O[C@@]3([H])[C@](CC5)([H])C4=C)([H])O2)[C@](C(C)(CC[C@@H]6O)C)([H])[C@@H]1O
Biological Activity: Ponicidin (Rubescensine B) is an orally active RIPK1 inhibitor with a Kd value of 135 nM. Ponicidin inhibits the JAK2/STAT3 pathway to induce apoptosis, activates the PI3K/Akt pathway, upregulates SIRT1 expression, alleviates oxidative stress, suppresses inflammatory responses and necroptosis, and blocks cell cycle progression. Ponicidin induces ROS production to exert antiproliferative and antiviral effects, while also improving cognitive function and reducing Aβ plaque deposition. Ponicidin can be used in studies related to hepatocellular carcinoma, Alzheimer's disease, and gastric cancer[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ponicidin | 99.93% | Ponicidin (Rubescensine B) is an orally active RIPK1 inhibitor with a Kd value of 135 nM. Ponicidin inhibits the JAK2/STAT3 pathway to induce apoptosis, activates the PI3K/Akt pathway, upregulates SIRT1 expression, alleviates oxidative stress, suppresses inflammatory responses and necroptosis, and blocks cell cycle progression. Ponicidin induces ROS production to exert antiproliferative and antiviral effects, while also improving cognitive function and reducing Aβ plaque deposition. Ponicidin can be used in studies related to hepatocellular carcinoma, Alzheimer's disease, and gastric cancer. | ||||||||||||||||||||
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- [1]. Zhang JF, et al. Ponicidin inhibits cell growth on hepatocellular carcinoma cells by induction of apoptosis. Dig Liver Dis. 2007 Feb;39(2):160-6. [Content Brief]
- [2]. Wang C, et al. Ponicidin attenuates Aβ1-42-induced hippocampal cell injury through SIRT1 and PI3K/Akt pathways. Mol Biol Rep. 2025;52(1):752. Published 2025 Jul 24. [Content Brief]
- [3]. Liu YF, et al. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. Int J Mol Sci. 2015;16(1):1576-1589. Published 2015 Jan 12. [Content Brief]
- [4]. Hu H, et al. Ponicidin ameliorates Alzheimer's disease through dual inhibition of RIPK1-mediated neuroinflammation and necroptosis. Int Immunopharmacol. 2026;171:116095. [Content Brief]
Keywords
