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PKM2-IN-1

27 Cited Publications
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Based on 27 publication(s) in Google Scholar

PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95 μM.

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  • Reinheit: 99.79%
  • CAS. Nr.: 94164-88-2
  • Formel: C18H19NO2S2
  • Molecular Weight:345.48
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • PKM2-IN-1 Chemical Structure
    PKM2-IN-1 Chemical Structure
  • Experimental Validation Results for PKM2-IN-1
  • Experimental Validation Results for PKM2-IN-1
  • Experimental Validation Results for PKM2-IN-1
  • Experimental Validation Results for PKM2-IN-1
  • Experimental Validation Results for PKM2-IN-1
CAS. Nr.: 94164-88-2
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  • PKM2-IN-1 Chemical Structure
    PKM2-IN-1 Chemical Structure
    1/16
  • 1/16

    PKM2-IN-1 purchased from MedChemExpress. Usage Cited in: Metabolism. 2025 Nov 6:175:156429. [Abstract]

    Customer Validation
     Pyruvate kinase activities of B16F10 cells after incubation with MTyr–OANPs, MTyr–OANPs + PKM inhibitor PKM2-IN-1 and MTyr–OANPs + PKM activator TEPP-46.

  • 1/16

    PKM2-IN-1 purchased from MedChemExpress. Usage Cited in: Metabolism. 2025 Nov 6:175:156429. [Abstract]

    Customer Validation
     Cell viabilities of indole-5,6-quinone, indole-5,6-quinone + PKM inhibitor PKM2-IN-1 and indole 5,6-quinone + PKM activator TEPP-46-treated, co-treated cells after 72 h.

  • 1/16

    PKM2-IN-1 purchased from MedChemExpress. Usage Cited in: Metabolism. 2025 Nov 6:175:156429. [Abstract]

    Customer Validation
     Immunofluorescence images showing SPP1 expression in control and Slc2a5− /− BV2 cells treated with C3k, with OGD at various time points.

  • 1/16

    PKM2-IN-1 purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2020 Apr;54:102722. [Abstract]

    Customer Validation
     ORO staining and quantification demonstrated that 10 μM PKM2-IN (a kinase inhibitor) could rescue the impaired adipogenic differentiation in the TRAF4-overexpressing group.

  • 1/16

    PKM2-IN-1 purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2020 Apr;54:102722. [Abstract]

    Customer Validation
     PKM2-IN (10 μM) decreased the active β-catenin expression in the TRAF4-overexpressing group to a level near that in the NC1 group.

  • PKM2-IN-1