Concanamycin F
Concanamycin F has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase (Ki=0.02 nM), which is an important tool for biochemical research.
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- CAS. Nr.: 144539-92-4
- Formel: C39H64O10
- Molecular Weight:692.92
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 144539-92-4
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Molecular Weight 692.92
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Formel C39H64O10
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SMILES
O=C1O[C@H]([C@@H](C)[C@@H](O)[C@@H]([C@@]2(O)C[C@@H](O)[C@H](C)[C@@H](/C=C/C)O2)C)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)[C@H](O)[C@H](C)/C=C(C)/C=C1\OC
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Structure Classification
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Initial Source
Streptomyces sp. A1509
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Reinheit & Dokumentation
Verweise
[1]. I Paterson I, et al. Total Synthesis of (+)-Concanamycin F We thank the EPSRC (GR/K54052), Knoll Pharmaceuticals (CASE Studentship to V.A.D.), the Cambridge Commonwealth Trust (M.D.M.), and Merck for support, and Dr R. Norrie (Knoll Pharmaceuticals) for helpful discussions. We also thank Prof. A. Zeeck (Göttingen) for kindly providing copies of (1)H NMR spectra of concanamycin F (concanolide A). Angew Chem Int Ed Engl. 2000 Apr;39(7):1308-1312. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Concanamycin F Related Classifications
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