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Art. -Nr.: HY-W747868

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Molidustat sodium

Name: Molidustat sodium
Brand: MedChemExpress
SKU: HY-W747868
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8 Cited Publications

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Based on 8 publication(s) in Google Scholar

Molidustat sodium is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC₅₀ values of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD3, respectively. Molidustat sodium can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat sodium can be utilized in the research of renal anemia.

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CAS. Nr.: 1375799-59-9
Formel: C₁₃H₁₃N₈NaO₂
Molecular Weight:336.28

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Molidustat sodium Chemical Structure

CAS. Nr.: 1375799-59-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (8)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 480 nM (PHD1), 280 nM (PHD2), 450 nM (PHD3)^[1]

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	0.28 μM Compound: 22; BAY-85-3934	Inhibition of recombinant human HIF-PHD2 expressed in insect Sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate after 60 mins by DELFIA Inhibition of recombinant human HIF-PHD2 expressed in insect Sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate after 60 mins by DELFIA	10.1039/C6MD00240D
Sf9	IC₅₀	0.45 μM Compound: 22; BAY-85-3934	Inhibition of recombinant human HIF-PHD3 expressed in insect Sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate after 60 mins by DELFIA Inhibition of recombinant human HIF-PHD3 expressed in insect Sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate after 60 mins by DELFIA	10.1039/C6MD00240D
Sf9	IC₅₀	0.48 μM Compound: 22; BAY-85-3934	Inhibition of recombinant human HIF-PHD1 expressed in insect Sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate after 60 mins by DELFIA Inhibition of recombinant human HIF-PHD1 expressed in insect Sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate after 60 mins by DELFIA	10.1039/C6MD00240D

In Vitro

Molidustat sodium (5 μM; 20 min) is sufficient to induce detectable levels of HIF-1α in HeLa cells. In a cell reporter assay, Molidustat sodium induces expression of a firefly luciferase reporter gene under the control of a hypoxia response element promoter with a mean (± SD) EC50 of 8.4 μM (n=4)^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Molidustat sodium, by stabilizing the hypoxia-inducible factor (HIF), leads to a dose-dependent increase in erythropoietin (EPO) in both Wistar rats (0.5-5 mg/kg; oral; once daily for 26 days) and cynomolgus monkeys (0.5-1.5mg/kg; once daily for 5 days)^[1].
Molidustat sodium (0.5-10 mg/kg; orally; five times weekly) can normalize the blood pressure in rat models of chronic kidney disease (CKD) and effectively alleviate renal anemia in rats with impaired renal function^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1375799-59-9
Molecular Weight 336.28
Formel C₁₃H₁₃N₈NaO₂
SMILES

[Na]OC1=C(N2N=NC=C2)C=NN1C3=NC=NC(N4CCOCC4)=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (8)

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Journal Impact Factor

Immunity

The transcriptional repressor Fli1 inhibits proteostasis during nutrient stress to limit NK cell persistence in solid tumors. [Abstract]

2026 Feb 18:S1074-7613(26)00035-X. PMID: 41713422
Cell Rep

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells. [Abstract]

2021 Apr 20;35(3):109020. PMID: 33852916
iScience

Excipient of paclitaxel induces metabolic dysregulation and unfolded protein response. [Abstract]

2021 Sep 25;24(10):103170. PMID: 34646996
Microb Pathog

Baicalin inhibits macrophage glycolysis and succinate-driven HIF-1α signaling by targeting PKM2 to alleviate RSV-induced inflammation. [Abstract]

2026 Apr:213:108291. PMID: 41544903
J Pharm Biomed Anal

Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]

2021 Feb 20:195:113870. PMID: 33453569
Drug Test Anal

Simultaneous detection of three hypoxia-inducible factor stabilizers-molidustat, roxadustat, and vadadustat-in multiple keratinized matrices and its application in a doping context. [Abstract]

2025 May;17(5):647-654. PMID: 38992954

Molidustat sodium purchased from MedChemExpress. Usage Cited in: Drug Test Anal. 2025 May;17(5):647-654. [Abstract]

Beard hair chromatogram. Molidustat concentration is 55 pg/mg. From bottom to top: Transition for internal standard testosterone-d3 (292.24 > 96.99) and two transitions of molidustat (315.0 > 137.10 and 315.10 > 207.00).
Biochem Biophys Res Commun

Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. [Abstract]

2018 Sep 3;503(1):297-303. PMID: 29890135

Molidustat sodium purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. [Abstract]

Effects of adaptaquin (10 mM) and Molidustat (10 mM) on Fe-8HQ (15 mM, 14 h)-induced LDH release in AML 12 cells.

Molidustat sodium purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. [Abstract]

Morphology of HT-1080 cells treated with Fe-8HQ (10 mM, 8 h) ± adaptaquin (10 mM) or Molidustat (10 mM).
bioRxiv

2023 Nov 2.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Flamme I, et al. Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects. PLoS One. 2014 Nov 13;9(11):e111838. [Content Brief]

[2]. Yamamoto H,et al. Molidustat for Renal Anemia in Nondialysis Patients Previously Treated with Erythropoiesis-Stimulating Agents: A Randomized, Open-Label, Phase 3 Study. Am J Nephrol. 2021;52(10-11):884-893. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Molidustat sodium

8 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (8)
Reinheit & Dokumentation
Verweise

1/16
1/16

Molidustat sodium purchased from MedChemExpress. Usage Cited in: Drug Test Anal. 2025 May;17(5):647-654. [Abstract]

Customer Validation
Beard hair chromatogram. Molidustat concentration is 55 pg/mg. From bottom to top: Transition for internal standard testosterone-d3 (292.24 > 96.99) and two transitions of molidustat (315.0 > 137.10 and 315.10 > 207.00).
1/16

Molidustat sodium purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. [Abstract]

Customer Validation
Effects of adaptaquin (10 mM) and Molidustat (10 mM) on Fe-8HQ (15 mM, 14 h)-induced LDH release in AML 12 cells.
1/16

Molidustat sodium purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. [Abstract]

Customer Validation
Morphology of HT-1080 cells treated with Fe-8HQ (10 mM, 8 h) ± adaptaquin (10 mM) or Molidustat (10 mM).

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Molidustat sodium

Publications Citing Use of MedChemExpress (MCE) Molidustat sodium

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen