Octenidine
Based on 4 publication(s) in Google Scholar
Octenidine is a potent antibacterial agent, possessing activity against multidrug-resistant Gram-negative pathogens. Octenidine can inhibit the expression of biofilm genes and destroy the formation of biofilms.
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- CAS. Nr.: 71251-02-0
- Formel: C36H62N4
- Molecular Weight:550.90
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Octenidine
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Biologische Aktivität
Beschreibung
In Vitro
Octenidine has antimicrobial activity against multidrug-resistant Gram-negative pathogens[1].
| Escherichia coli | Pseudomonas aeruginosa | |||||||||
| WT | CTX-M-1 | CTX-M-15 | NDM-1 | VIM-15 | WT | PER-1 | VEB-1 | OprD | VIM-2 | |
| MIC (mg/L) | 0.5 | 2.5 | 1.2 | 5 | 2.5 | 10 | 40 | 40 | 40 | 40 |
Octenidine (0-20 h) retardants P. aeruginosa growth in prolonged exposure condition[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice (a six-millimetre punch full-thickness wound was inoculated with MRSA suspension)[3]
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Dosage:
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Administration:Administrated once 24 hours post-wounding
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Result:Accelerated healing and reduced by >3.6 log cfu/g bacterial counts on the wounds relative to the PBS-treated control.
Exhibited lower burden of the inflammatory cells, more mature collagen fibres and well-defined epithelialisation.
Inhibited the expression of MRSA and its biofilm genes by nearly 100%.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 71251-02-0
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Molecular Weight 550.90
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Formel C36H62N4
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SMILES
CCCCCCCC/N=C1C=CN(CCCCCCCCCCN(C=C/2)C=CC2=N/CCCCCCCC)C=C/1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Antioxidants (Basel)
Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species. [Abstract]2024 May 29;13(6):667. PMID: 38929106 -
Antiviral Res
Repurposing screen using a robust human rhinovirus infectious clone identifies pyrvinium pamoate with antiviral activity. [Abstract]2026 Jun:250:106417. PMID: 42025967 -
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Reinheit & Dokumentation
Verweise
[1]. Alvarez-Marin R, et al. Antimicrobial activity of octenidine against multidrug-resistant Gram-negative pathogens. Eur J Clin Microbiol Infect Dis. 2017 Dec;36(12):2379-2383. [Content Brief]
[2]. Conceição T, et al. Efficacy of octenidine against antibiotic-resistant Staphylococcus aureus epidemic clones. J Antimicrob Chemother. 2016 Oct;71(10):2991-4. [Content Brief]
[3]. Huang J, et al. Octenidine dihydrochloride treatment of a meticillin-resistant Staphylococcus aureus biofilm-infected mouse wound. J Wound Care. 2021 Feb 2;30(2):106-114. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Octenidine Related Classifications
HY-B2170 Related Classifications
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