PC Alkyne-PEG4-NHS ester
Based on 1 publication(s) in Google Scholar
PC Alkyne-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). PC Alkyne-PEG4-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- Reinheit : 97.88%
- CAS. Nr.: 1802907-98-7
- Formel: C29H39N3O14
- Molecular Weight:653.63
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Speicherung:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PC Alkyne-PEG4-NHS ester
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Biologische Aktivität
Beschreibung
IC50 & Target
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Cleavable Linker |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1802907-98-7
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Appearance Viscous Liquid
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Molecular Weight 653.63
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Formel C29H39N3O14
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Color Light yellow to yellow
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SMILES
O=C(OC(C1=CC(OC)=C(OCCCC(NCCOCCOCCOCCOCC#C)=O)C=C1[N+]([O-])=O)C)ON2C(CCC2=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Colloids Surf B Biointerfaces
Suppressing angiogenic phenotypes in retinal cell models through light-triggered anti-VEGF release from upconversion nanoparticle-loaded chitosan microgels. [Abstract]2026 Jun 25:267:115936. PMID: 42372461
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (152.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (267 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5299 mL | 7.6496 mL | 15.2992 mL | 38.2479 mL |
| 5 mM | 0.3060 mL | 1.5299 mL | 3.0598 mL | 7.6496 mL | |
| 10 mM | 0.1530 mL | 0.7650 mL | 1.5299 mL | 3.8248 mL | |
| 15 mM | 0.1020 mL | 0.5100 mL | 1.0199 mL | 2.5499 mL | |
| 20 mM | 0.0765 mL | 0.3825 mL | 0.7650 mL | 1.9124 mL | |
| 25 mM | 0.0612 mL | 0.3060 mL | 0.6120 mL | 1.5299 mL | |
| 30 mM | 0.0510 mL | 0.2550 mL | 0.5100 mL | 1.2749 mL | |
| 40 mM | 0.0382 mL | 0.1912 mL | 0.3825 mL | 0.9562 mL | |
| 50 mM | 0.0306 mL | 0.1530 mL | 0.3060 mL | 0.7650 mL | |
| 60 mM | 0.0255 mL | 0.1275 mL | 0.2550 mL | 0.6375 mL | |
| 80 mM | 0.0191 mL | 0.0956 mL | 0.1912 mL | 0.4781 mL | |
| 100 mM | 0.0153 mL | 0.0765 mL | 0.1530 mL | 0.3825 mL |
PC Alkyne-PEG4-NHS ester Related Classifications
HY-140139 Related Classifications
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