RXFP2 agonist 2
Based on 1 Customer Validation
RXFP2 agonist 2 is a selective, orally active and allosteric RXFP2 agonist with an EC50 value of 0.38 μM. RXFP2 agonist 2 induces osteoblast mineralization. RXFP2 agonist 2 increases bone formation in female mice. RXFP2 agonist 2 has the potential for the research of osteoporosis.
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- Reinheit : 99.59%
- CAS. Nr.: 2971704-85-3
- Formel: C29H19F9IN3O5
- Molecular Weight:787.37
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
EC50: 0.38 µM (RXFP2)[1]
In Vitro
RXFP2 agonist 2 (Compound 6641) (1, 3, 5 µM; 14 days) induces osteoblast mineralization at 3 and 5 µM with no cytotoxicity in HCO cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCO cells
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Concentration:0-100 µM
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Incubation Time:14 days
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Result:Induced mineralization of primary human osteoblasts and is non-cytotoxic.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-week-old WT C57BL/6 J female mice[1]
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Dosage:3 mg/kg for i.v.; 10 mg/kg for p.o.
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Administration:I.v. or p.o.
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Result:Exhibited a half-life of between 4-6.5 h depending on the route of administration, with no accumulation at 10 mg/kg, and oral bioavailability around 25-31%.
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Animal Model:8-week-old WT C57BL/6 J female mice[1]
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Dosage:10 mg/kg
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Administration:P.o.; 3 times per week for 8 weeks
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Result:Increased bone formation in mouse with significantly increased in Tb.N and Tb.Th, and increased BV/TV and decreased Tb.Sp.
Chemical Information
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CAS. Nr. 2971704-85-3
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Appearance Solid
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Molecular Weight 787.37
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Formel C29H19F9IN3O5
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Color White to off-white
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SMILES
O=C(N1[C@H]2CN(CC1)C(COC3=CC=C(C=C3I)OC(F)(F)F)=O)C4=CC(C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=CC=C4NC2=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
RXFP2 agonist 2 Related Classifications
HY-150186 Related Classifications
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