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Art. -Nr.: HY-120600

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Sibiriline

Sibiriline is a specific competitive inhibitor of RIPK1 that targets the RIPK1 ATP-binding site and locks it in an inactive conformation. Sibiriline inhibits TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis, but does not protect cells from caspase-dependent apoptosis. Sibiriline protects mice from concanavalin A-induced hepatitis and has the potential to inhibit immune-dependent hepatitis..

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CAS. Nr.: 1346526-26-8
Formel: C₁₃H₁₀N₂O
Molecular Weight:210.23

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Sibiriline Chemical Structure

CAS. Nr.: 1346526-26-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- IC₅₀ & Target
- Cellular Effect
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

RIPK1^[1]

Alle RIP kinase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	EC₅₀	1.2 μM Compound: L7	Cytotoxicity against human Jurkat cells assessed as cell viability measured after 24 hrs by MTT assay Cytotoxicity against human Jurkat cells assessed as cell viability measured after 24 hrs by MTT assay	[PMID: 38199165]
Jurkat	EC₅₀	1200 nM Compound: 48	Anti-neprotic activity in human Jurkat cells assessed as reduction in TNF-induced necroptosis incubated for 24 hrs by MTS assay Anti-neprotic activity in human Jurkat cells assessed as reduction in TNF-induced necroptosis incubated for 24 hrs by MTS assay	[PMID: 31622096]
Jurkat	IC₅₀	1200 nM Compound: 64	Anti-necroptic activity in TNF alpha induced necroptosis in FADD-deficient human Jurkat cells incubated for 24 hrs by MTS reduction assay Anti-necroptic activity in TNF alpha induced necroptosis in FADD-deficient human Jurkat cells incubated for 24 hrs by MTS reduction assay	[PMID: 36346971]
L929	CC₅₀	>50 μM Compound: Sibiriline	Cytotoxicity against mouse L929 cells by CCK-8 assay Cytotoxicity against mouse L929 cells by CCK-8 assay	[PMID: 36801518]
L929	EC₅₀	1.31 μM Compound: Sibiriline	Anti-necroptosis activity against TNFalpha/z-VAD-fmk-induced mouse L929 cell necroptosis model assessed as cell viability pretreated with compound for 1 hr followed by treated with TZ for 6 hrs Anti-necroptosis activity against TNFalpha/z-VAD-fmk-induced mouse L929 cell necroptosis model assessed as cell viability pretreated with compound for 1 hr followed by treated with TZ for 6 hrs	[PMID: 36801518]
Sf9	IC₅₀	1030 nM Compound: 48	Inhibition of human full length GST-tagged RIPK1 expressed in baculovirus in Sf9 insect cells incubated for 10 mins in presence of [gamma32-ATP] by SDS-PAGE based topcount scintillation counting method Inhibition of human full length GST-tagged RIPK1 expressed in baculovirus in Sf9 insect cells incubated for 10 mins in presence of [gamma32-ATP] by SDS-PAGE based topcount scintillation counting method	[PMID: 31622096]

Chemical Information

CAS. Nr. 1346526-26-8
Molecular Weight 210.23
Formel C₁₃H₁₀N₂O
SMILES

OC1=CC=C(C=C1)C2=CC3=CC=CN=C3N2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sibirilin e, a new small chemical inhibitor of Receptor - Interacting Protein Kinase 1 , prevents immune -dependent hepatitis

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Sibiriline

Alle RIP kinase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

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Sibiriline Related Classifications

HY-120600 Related Classifications