1346526-26-8
Chemical Structure
Sibiriline
- CAS No.: 1346526-26-8
- Formula:C13H10N2O
- Molecular Weight:210.23
IUPAC Name: 4-(1H-pyrrolo[2,3-b]pyridin-2-yl)phenol
InChIKey: XZQLYCMLGSOHOX-UHFFFAOYSA-N
SMILES: OC1=CC=C(C=C1)C2=CC3=CC=CN=C3N2
Biological Activity: Sibiriline is a specific competitive inhibitor of RIPK1 that targets the RIPK1 ATP-binding site and locks it in an inactive conformation. Sibiriline inhibits TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis, but does not protect cells from caspase-dependent apoptosis. Sibiriline protects mice from concanavalin A-induced hepatitis and has the potential to inhibit immune-dependent hepatitis.[1].
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Sibiriline | Sibiriline is a specific competitive inhibitor of RIPK1 that targets the RIPK1 ATP-binding site and locks it in an inactive conformation. Sibiriline inhibits TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis, but does not protect cells from caspase-dependent apoptosis. Sibiriline protects mice from concanavalin A-induced hepatitis and has the potential to inhibit immune-dependent hepatitis.. | |||||||||||||||||||||
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Keywords
