Stellettamide A TFA
Stellettamide A TFA is a marine toxin found in a marine sponge. Stellettamide A TFA is a calmodulin inhibitor. Stellettamide A TFA can inhibit Ca2+/Mg2+ ATPase, phosphodiesterase, myosin light chain , and Mg2+-ATPase. Stellettamide A TFA inhibits high K+- and Ca2+-induced contraction in permeabilized smooth muscle. Stellettamide A TFA exhibits antifungal activity against Mortierella remannianus. Stellettamide A TFA can be used for the research of fungal infection.
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- CAS. Nr.: 129744-24-7
- Formel: C28H46F3N2O3+
- Molecular Weight:515.67
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Stellettamide A TFA (3-300 μM; 1 h) inhibits Ca2+-stimulated Mg2+-ATPase activity in native actomyosin from chicken gizzard with an IC50 of 25 μM[1].
Stellettamide A TFA (3-300 μM) inhibits myosin light chain phosphorylation in a reconstituted smooth muscle contractile system with an IC50 of 152 μM, and this effect is antagonized by higher calmodulin concentrations[1].
Stellettamide A TFA (3-300 μM) inhibits Ca2+/calmodulin-dependent (Ca2+-Mg2+)-ATPase from rabbit erythrocyte membranes (IC50 = 100 μM) and phosphodiesterase from bovine heart (IC50 = 52 μM), with the latter effect antagonized by higher calmodulin concentrations[1].
Stellettamide A TFA (3-300 μM) quenches calmodulin’s intrinsic tyrosine fluorescence in a concentration-dependent manner with or without Ca2+, indicating direct binding independent of Ca2+[1].
Stellettamide A TFA inhibits high
K+(72.7 mM), Ca2+(3 mM and 10 mM)-induced contraction in the smooth muscle of guinea-pig taenia coli with an IC50 of 88, 46 and 105 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 129744-24-7
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Molecular Weight 515.67
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Formel C28H46F3N2O3+
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SMILES
OC(C(F)(F)F)=O.C[N@@+]12[C@@](CCCC2)([H])[C@@H](CC1)CNC(/C=C/[C@@H](C)CC/C=C(C)/CC/C=C(C)/C)=O
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Synonyms
ST-A TFA
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Stellettamide A TFA Related Classifications
HY-N18431 Related Classifications
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- Stellettamide A
- 129744-24-7
- ST-A
- Fungal
- bovine cardiac muscle phosphodiesterase
- chicken gizzard native actomyosin Mg2?-ATPase
- Ca2?/calmodulin-dependent enzyme activities
- MLC phosphorylation
- chicken myosin light chain kinase
- calmodulin
- Mortierella remannianus
- smooth muscle contraction
- rabbit erythrocyte membrane Ca2?/Mg2? ATPase
- epithelium cells
- Inhibitor
- inhibitor
- inhibit