TC-S 7005
Based on 4 publication(s) in Google Scholar
TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.68%
- CAS. Nr.: 1082739-92-1
- Formel: C21H17N3O3
- Molecular Weight:359.38
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Publications Citing Use of MedChemExpress (MCE) TC-S 7005
More
Biologische Aktivität
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PLK2 4 nM (IC50) |
PLK3 24 nM (IC50) |
PLK1 214 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
7.32 μM
Compound: 9
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Cell cycle arrest in human HCT 116 cells assessed as doubling of DNA content by high-content cell screening assay
Cell cycle arrest in human HCT 116 cells assessed as doubling of DNA content by high-content cell screening assay
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[PMID: 18790636] |
TC-S 7005 markedly induces myofibroblast differentiation and reduces fibroblast proliferation rates[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary human SR fibroblasts
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Concentration:1 μM
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Incubation Time:7 days
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Result:Markedly induced myofibroblast differentiation and reduced fibroblast proliferation rates.
Chemical Information
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CAS. Nr. 1082739-92-1
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Appearance Solid
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Molecular Weight 359.38
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Formel C21H17N3O3
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Color Light yellow to yellow
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SMILES
C[C@H](NC1=CC2=C(ON=C2C3=CC=C(OCO4)C4=C3)C=N1)C5=CC=CC=C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (4)
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Journal Impact Factor
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Most Recent
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Autophagy
2025 Aug;21(8):1623-1643. PMID: 39773002 -
Cell Rep
Polo-like kinase 2 promotes microglial activation via regulation of the HSP90α/IKKβ pathway. [Abstract]2024 Oct 8;43(10):114827. PMID: 39383034 -
Exp Cell Res
2022 Aug 1;417(1):113181. PMID: 35523306 -
PLoS One
A novel small molecule screening assay using normal human chondrocytes toward osteoarthritis drug discovery. [Abstract]2024 Nov 1;19(11):e0308647. PMID: 39485774
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (347.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7826 mL | 13.9128 mL | 27.8257 mL | 69.5642 mL |
| 5 mM | 0.5565 mL | 2.7826 mL | 5.5651 mL | 13.9128 mL | |
| 10 mM | 0.2783 mL | 1.3913 mL | 2.7826 mL | 6.9564 mL | |
| 15 mM | 0.1855 mL | 0.9275 mL | 1.8550 mL | 4.6376 mL | |
| 20 mM | 0.1391 mL | 0.6956 mL | 1.3913 mL | 3.4782 mL | |
| 25 mM | 0.1113 mL | 0.5565 mL | 1.1130 mL | 2.7826 mL | |
| 30 mM | 0.0928 mL | 0.4638 mL | 0.9275 mL | 2.3188 mL | |
| 40 mM | 0.0696 mL | 0.3478 mL | 0.6956 mL | 1.7391 mL | |
| 50 mM | 0.0557 mL | 0.2783 mL | 0.5565 mL | 1.3913 mL | |
| 60 mM | 0.0464 mL | 0.2319 mL | 0.4638 mL | 1.1594 mL | |
| 80 mM | 0.0348 mL | 0.1739 mL | 0.3478 mL | 0.8696 mL | |
| 100 mM | 0.0278 mL | 0.1391 mL | 0.2783 mL | 0.6956 mL |
TC-S 7005 Related Classifications
HY-108597 Related Classifications
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