dCASP1-55
dCASP1-55 is a cereblon-dependent caspase-1 (CASP1) PROTAC degrader. dCASP1-55 induces excessive NF-κB activation, apoptosis, and moderate S-phase arrest in leukemic cells. dCASP1-55 suppresses colony formation of leukemic cells. dCASP1-55 can be used for the research of cancer, such as myeloid malignancies and acute myeloid leukemia.
(Pink: Caspase-1 ligand (HY-13205); Blue: Cereblon ligand (HY-10984); Black: linker (HY-W067705)).
For research use only. We do not sell to patients.
- Formula: C45H54ClN7O15
- Molecular Weight:968.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Caspase-1 |
Cereblon |
dCASP1-55 (25-1000 nM; 0-6 h) selectively degrades CASP1 in THP1, MDSL, and AML cells, suppresses their colony formation, induces excessive NF-κB activation, and induces apoptosis, and moderate S-phase arrest[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP1, MDSL, and AML cells
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Concentration:50, 100, 200 and 300 nM
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Incubation Time:6 h
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Result:Decreased CASP1 levels.
Increased p-RelA levels.
Chemical Information
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Molecular Weight 968.40
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Formula C45H54ClN7O15
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SMILES
CCO[C@@H]1OC(C[C@@H]1NC([C@@H]2CCCN2C([C@H](C(C)(C)C)NC(C3=CC(Cl)=C(C=C3)NC(COCCOCCOCC(NC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
dCASP1-55 Related Classifications
HY-181132 Related Classifications
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