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CLIC3 - chloride intracellular channel 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9022

About CLIC3

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,994,608-136,996,568 (from NCBI)

This gene has 3 transcripts (splice variants), 225 orthologues and 14 paralogues. Biased expression in esophagus (RPKM 23.8), thyroid (RPKM 21.4) and 5 other tissues.

Summary

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]

CLIC3 Products (1)

mRNA	Protein	Name
NM_004669.3	NP_004660.2	chloride intracellular channel protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chloride channel activity	IMP IMP: Inferred from mutant phenotype	9880541	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9880541	GOA
enables protein-disulfide reductase (glutathione) activity	IDA IDA: Inferred from direct assay	28198360	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chloride transport	IMP IMP: Inferred from mutant phenotype	9880541	GOA
involved in positive regulation of sprouting angiogenesis	IDA IDA: Inferred from direct assay	28198360	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9880541	GOA
located in extracellular matrix	IDA IDA: Inferred from direct assay	28198360	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9880541	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLIC3 Protein Structure

GST_N_3

GST_C_2

0
100
200
236 a.a.

Protein Preferred Names	Protein Names
chloride intracellular channel protein 3

CLIC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLIC3	O95833	SPMIP4	Homo sapiens	Q8N865	Y2H Array	32296183
Intra	CLIC3	O95833	SPMIP4	Homo sapiens	Q8N865	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	SPMIP4	Homo sapiens	Q8N865	Validated Y2H	32296183
Intra	CLIC3	O95833	KRTAP13-3	Homo sapiens	Q3SY46	Validated Y2H	32296183
Intra	CLIC3	O95833	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Array	32296183
Intra	CLIC3	O95833	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	SPMIP6	Homo sapiens	Q8NCR6	Validated Y2H	32296183
Intra	CLIC3	O95833	SPMIP6	Homo sapiens	Q8NCR6	Y2H Array	32296183
Intra	CLIC3	O95833	SPMIP6	Homo sapiens	Q8NCR6	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	KRT85	Homo sapiens	P78386	Validated Y2H	32296183
Intra	CLIC3	O95833	KRT85	Homo sapiens	P78386	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	KRT85	Homo sapiens	P78386	Y2H Array	32296183
Intra	CLIC3	O95833	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	CLIC3	O95833	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	CLIC3	O95833	VPS4A	Homo sapiens	Q9UN37	Y2H Array	32296183
Intra	CLIC3	O95833	VPS4A	Homo sapiens	Q9UN37	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	VPS4A	Homo sapiens	Q9UN37	Validated Y2H	32296183
Intra	CLIC3	O95833	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	CLIC3	O95833	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	CLIC3	O95833	GLYR1	Homo sapiens	Q49A26-4	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	GLYR1	Homo sapiens	Q49A26-4	Y2H Array	32296183
Intra	CLIC3	O95833	GLYR1	Homo sapiens	Q49A26-4	Validated Y2H	32296183
Intra	CLIC3	O95833	CIMIP2B	Homo sapiens	A8MTA8-2	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	CIMIP2B	Homo sapiens	A8MTA8-2	Y2H Array	32296183
Intra	CLIC3	O95833	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
Intra	CLIC3	O95833	MBD3L1	Homo sapiens	Q8WWY6	Validated Y2H	32296183
Intra	CLIC3	O95833	MBD3L1	Homo sapiens	Q8WWY6	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	MBD3L1	Homo sapiens	Q8WWY6	Y2H Array	32296183
Intra	CLIC3	O95833	PROSER2	Homo sapiens	Q86WR7-2	Validated Y2H	32296183
Intra	CLIC3	O95833	PROSER2	Homo sapiens	Q86WR7-2	Y2H Array	32296183
Intra	CLIC3	O95833	PROSER2	Homo sapiens	Q86WR7-2	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	ZC2HC1C	Homo sapiens	Q53FD0-2	Validated Y2H	32296183
Intra	CLIC3	O95833	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Array	32296183
Intra	CLIC3	O95833	ANKRD55	Homo sapiens	Q3KP44	Y2H Array	32296183
Intra	CLIC3	O95833	ANKRD55	Homo sapiens	Q3KP44	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	ANKRD55	Homo sapiens	Q3KP44	Validated Y2H	32296183
Intra	CLIC3	O95833	SCML4	Homo sapiens	Q8N228-3	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	SCML4	Homo sapiens	Q8N228-3	Validated Y2H	32296183
Intra	CLIC3	O95833	SCML4	Homo sapiens	Q8N228-3	Y2H Array	32296183
Intra	CLIC3	O95833	LELP1	Homo sapiens	Q5T871	Validated Y2H	32296183
Intra	CLIC3	O95833	LELP1	Homo sapiens	Q5T871	Y2H Array	32296183
Intra	CLIC3	O95833	LELP1	Homo sapiens	Q5T871	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	TBC1D3F	Homo sapiens	A6NER0	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	TBC1D3F	Homo sapiens	A6NER0	Y2H Array	32296183
Intra	CLIC3	O95833	MIA3	Homo sapiens	Q5JRA6	Validated Y2H	32296183
Intra	CLIC3	O95833	MIA3	Homo sapiens	Q5JRA6	Y2H Array	32296183
Intra	CLIC3	O95833	MIA3	Homo sapiens	Q5JRA6	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	25416956
Intra	CLIC3	O95833	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	25416956
Intra	CLIC3	O95833	MECOM	Homo sapiens	Q03112-9	Validated Y2H	32296183
Intra	CLIC3	O95833	MECOM	Homo sapiens	Q03112-9	Y2H Array	32296183
Intra	CLIC3	O95833	MECOM	Homo sapiens	Q03112-9	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	ZNF620	Homo sapiens	Q6ZNG0	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	ZNF620	Homo sapiens	Q6ZNG0	Validated Y2H	32296183
Intra	CLIC3	O95833	ZNF620	Homo sapiens	Q6ZNG0	Y2H Array	32296183
Intra	CLIC3	O95833	ANKRD23	Homo sapiens	Q86SG2	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	ANKRD23	Homo sapiens	Q86SG2	Validated Y2H	32296183
Intra	CLIC3	O95833	ANKRD23	Homo sapiens	Q86SG2	Y2H Array	32296183
Intra	CLIC3	O95833	MSX2	Homo sapiens	P35548	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	MSX2	Homo sapiens	P35548	Validated Y2H	32296183
Intra	CLIC3	O95833	MSX2	Homo sapiens	P35548	Y2H Array	32296183
Intra	CLIC3	O95833	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32296183
Intra	CLIC3	O95833	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	CLIC3	O95833	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	AGR2	Homo sapiens	O95994	Validated Y2H	32296183
Intra	CLIC3	O95833	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	CLIC3	O95833	KATNBL1	Homo sapiens	Q9H079	Validated Y2H	32296183
Intra	CLIC3	O95833	KATNBL1	Homo sapiens	Q9H079	Y2H Array	32296183
Intra	CLIC3	O95833	KATNBL1	Homo sapiens	Q9H079	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	STMN3	Homo sapiens	Q9NZ72	Validated Y2H	32296183
Intra	CLIC3	O95833	STMN3	Homo sapiens	Q9NZ72	Y2H Array	32296183
Intra	CLIC3	O95833	STMN3	Homo sapiens	Q9NZ72	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	CLIC3	O95833	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	CLIC3	O95833	ALX1	Homo sapiens	Q15699	Y2H Array	32296183
Intra	CLIC3	O95833	ALX1	Homo sapiens	Q15699	Y2H Prey Pooling	32296183
Intra	CLIC3	O95833	ALX1	Homo sapiens	Q15699	Validated Y2H	32296183
Intra	CLIC3	O95833	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950
Intra	CLIC3	O95833	POT1	Homo sapiens	Q9NUX5	BiFC	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLIC3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7857	CLIC3 Protein, Human (His)	O95833 (M1-R236)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02805	CLIC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17974	Clic3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24445	Clic3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CLIC3	RGD	RGD:1307249
Macaca mulatta	CLIC3	VGNC	VGNC:71255
Canis familiaris	CLIC3	VGNC	VGNC:39339
Bos taurus	CLIC3	VGNC	VGNC:27441
Mus musculus	CLIC3	MGD	MGI:1916704
Felis catus	CLIC3	VGNC	VGNC:60960
Others	CLIC3	NCBI