2-MPMDQ
2-MPMDQ is a potent and selective α1-adrenoceptor (Ki=0.37 nM) antagonist over α2-adrenoceptor (Ki=1740 nM). 2-MPMDQ is potent anti-hypertensive agent and has the potential for hypertension research.
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- CAS No.: 149847-77-8
- Formule: C23H27N5O2
- Masse moléculaire:405.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
α1-adrenergic receptor 0.37 nM (Ki) |
α2-adrenergic receptor 1740 nM (Ki) |
Chemical Information
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CAS No. 149847-77-8
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Masse moléculaire 405.49
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Formule C23H27N5O2
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SMILES
O=C1N(C)C2=C(C=CC=C2)C3=NC(CN4CCN(C5=CC=CC=C5OC)CC4)CN13
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-MPMDQ Related Classifications
HY-101061 Related Classifications
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