FR 78844
FR 78844 is an orally active bone resorption inhibitor. FR 78844 attenuates metaphyseal bone mineral density decreases in Streptozotocin (HY-13753)-induced diabetic rats, and Heparin (HY-17567A)-induced osteopenia, but does not affect vitamin D-deficient rat bone loss. FR 78844 can be used for the research of osteopenia.
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- CAS No.: 112856-39-0
- Formule: C8H9NNa2O6P2S
- Masse moléculaire:355.15
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
FR 78844 potently inhibits PTH-induced calcium release from rat calvaria in vitro with an IC50 of 4.4 × 10-7 M[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
FR 78844 (1-100 mg/kg; p.o.; 5 days a week; 4 weeks) significantly attenuates ovariectomy-induced osteopenic bone loss in rats[1].
FR 78844 (1-100 mg/kg; p.o.; 5 days a week; 4 weeks) does not attenuate vitamin D deficiency-induced osteopenic bone loss in rats[1].
FR 78844 (1-100 mg/kg; p.o.; 5 days a week; 4 weeks) dose-dependently attenuates Heparin-induced osteopenia in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (9-week-old female; Streptozotocin (STZ)-induced diabetic model)[1]
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Dosage:1; 10; 100 mg/kg
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Administration:p.o.; 5 days a week; 4 weeks
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Result:Attenuated the decrease in femur metaphyseal bone mineral density by 66% at 100 mg/kg dose compared to vehicle-treated STZ rats.
Did not produce a significant effect at 1 mg/kg and 10 mg/kg doses.
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Animal Model:Wistar rats (9-week-old female; ovariectomized model)[1]
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Dosage:1; 10; 100 mg/kg
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Administration:p.o.; 5 days a week; 4 weeks
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Result:Attenuated the decrease in femur metaphyseal bone mineral density by 81% at 100 mg/kg dose compared to vehicle-treated ovariectomized rats.
Did not produce a significant effect at 1 mg/kg and 10 mg/kg doses.
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Animal Model:Wistar rats (4-week-old female; vitamin D-deficient model)[1]
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Dosage:1; 10; 100 mg/kg
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Administration:p.o.; 5 days a week; 4 weeks
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Result:Did not produce a significant effect on femur metaphyseal bone mineral density at any tested dose compared to vehicle-treated vitamin D-deficient rats.
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Animal Model:Wistar rats (female, 9 weeks old, osteopenia induced by Heparin sodium 2000 U/kg·day subcutaneously 5 days a week for 4 weeks)[2]
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Dosage:1; 10; 100 mg/kg
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Administration:p.o.; 5 days a week; 4 weeks
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Result:Attenuated the heparin-induced decrease in metaphyseal bone mineral density in a dose-dependent manner.
Produced a significant increase in metaphyseal bone mineral density at 100 mg/kg compared to the vehicle-treated heparinized group.
Showed a significant improvement in metaphyseal bone mineral density at 10 mg/kg relative to the vehicle group.
Chemical Information
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CAS No. 112856-39-0
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Masse moléculaire 355.15
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Formule C8H9NNa2O6P2S
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SMILES
S=C(NC1=CC=CC=C1)C(P(O)(O)=O)P(O[Na])(O[Na])=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Takeshita N, et al. Possible involvement of vitamin D3-deficiency and relatively enhanced bone resorption in the development of bone loss in streptozotocin-induced diabetic rats. Life Sci. 1994;55(4):291-9. [Content Brief]
[2]. Mutoh S, et al. Characterization of heparin-induced osteopenia in rats. Endocrinology. 1993 Dec;133(6):2743-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FR 78844 Related Classifications
HY-122075 Related Classifications
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