Pifexole
Pifexole is a biologically active 3,5-disubstituted-1,2,4-oxadiazole compound. Pifexole exhibits antispasmodic and muscle relaxant activities, with no effect on monosynaptic knee-jerk reflex. Pifexole can be used in studies related to muscle relaxation and spasm.
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- CAS No.: 27199-40-2
- Formule: C13H8ClN3O
- Masse moléculaire:257.68
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Pifexole (15.4-200 mg/kg; p.o.) inhibits electroshock-induced convulsions in rats and mice with ED50 values of 17.5 mg/kg and 15.4 mg/kg, respectively, and inhibits strychnine-induced convulsions in both species with an ED50 of 96 mg/kg, while antagonizing nicotine toxicity in mice with an ED50 of 30 mg/kg. Pifexole also reduces muscle strength in mice by 25% and 35% at 100 mg/kg and 200 mg/kg, respectively, inhibits spontaneous activity in mice at 100 mg/kg, and reduces morphine-induced excitation and hyperactivity at 200 mg/kg[2]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Polysynaptic crossed extensor and monosynaptic patellar reflex assays in chloralose-urethane-anesthetized cats[2]
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Dosage:5, 10, 20 mg/kg
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Administration:i.v.; single administration; monitored for approximately 20-25 min
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Result:Reduced the polysynaptic crossed extensor reflex by 81.6% and 93.1% at 5 and 10 mg/kg, respectively.
Did not affect the monosynaptic patellar reflex at 10-20 mg/kg.
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Animal Model:Nicotine toxicity[2]
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Dosage:30, 100, 200 mg/kg
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Administration:p.o. for the nicotine toxicity assay
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Result:Antagonized nicotine toxicity with an ED50 of 30 mg/kg.
Reduced muscle strength by 25% and 35% at 100 and 200 mg/kg, respectively.
Suppressed spontaneous locomotor activity at 100 mg/kg and reduced morphine-induced excitation and hypermotility at 200 mg/kg.
Chemical Information
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CAS No. 27199-40-2
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Masse moléculaire 257.68
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Formule C13H8ClN3O
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SMILES
ClC=1C=CC=CC1C2=NC(=NO2)C=3C=CN=CC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pifexole Related Classifications
HY-W291147 Related Classifications
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