2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Wnt Casein Kinase
  4. CK2-IN-9

CK2-IN-9 is a potent and selective inhibitor of CK2 kinase with an IC50 of 3 nM. CK2-IN-9 reduces Wnt reporter activity with an IC50 of 75 nM. CK2-IN-9 has low exposure (AUC=0.36 μM/h) and high clearance (CL=65 mL/min/kg) properties in rat.

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CK2-IN-9

CK2-IN-9 Estructura química

No. CAS : 1461658-58-1

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CK2-IN-9 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas Wnt:

Ver todas las isoformas
Wnt1 Wnt2 Wnt3 Wnt5 Wnt7 Wnt11

Ver todos los productos específicos de isoformas Casein Kinase:

Ver todas las isoformas
CK1 CK2

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Descripciòn

CK2-IN-9 is a potent and selective inhibitor of CK2 kinase with an IC50 of 3 nM. CK2-IN-9 reduces Wnt reporter activity with an IC50 of 75 nM. CK2-IN-9 has low exposure (AUC=0.36 μM/h) and high clearance (CL=65 mL/min/kg) properties in rat[1].

Cellular Effect
Cell Line Type Value Description References
CHO IC50
4 μM
Compound: 7b
Inhibition of human ERG expressed in CHO cells by patch clamp assay
Inhibition of human ERG expressed in CHO cells by patch clamp assay
[PMID: 26985319]
DLD-1 GI50
0.08 μM
Compound: 7b
Antiproliferative activity against human DLD1 cells after 72 hrs by alamar blue assay
Antiproliferative activity against human DLD1 cells after 72 hrs by alamar blue assay
[PMID: 26985319]
HCT-116 GI50
0.03 μM
Compound: 7b
Antiproliferative activity against human HTC116 cells after 72 hrs by alamar blue assay
Antiproliferative activity against human HTC116 cells after 72 hrs by alamar blue assay
[PMID: 26985319]
HCT-116 GI50
0.03 μM
Compound: Example 1
Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay
Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay
[PMID: 24900617]
Sf21 IC50
<0.003 μM
Compound: 7b
Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 90 mins by mobility shift assay
Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 90 mins by mobility shift assay
[PMID: 26985319]
SW-620 GI50
0.03 μM
Compound: 7b
Antiproliferative activity against human SW620 cells after 72 hrs by alamar blue assay
Antiproliferative activity against human SW620 cells after 72 hrs by alamar blue assay
[PMID: 26985319]
Peso molecular

447.54

Fòrmula

C23H29N9O
No. CAS
SMILES

O=C(C)NC1=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=CC=C1N(CCN(C)C)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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CK2-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CK2-IN-91461658-58-1WntCasein KinaseCK2 kinase Inhibitorβ-cateninInhibitorinhibitorinhibit

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Nombre del producto:
CK2-IN-9
Cat. No.:
HY-12570
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